| Entrez gene ID | | 11727 |
|
| Official gene symbol | | Ang |
|
| Full name | | angiogenin, ribonuclease, RNase A family, 5 |
|
| Aliases | | AI385586,Ang1,Rnase5,Rnase5a |
|
| Gene summary | | This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq] |
|
| Location | | Chromosome: 14 Locus: 14 B-C1|14 18.0 cM |
|
| Gene position | | 51710752 - 51721684 Map Viewer |
|
| Gene orientation | | plus |
|
| Gene size | | 10933 bp |
|
| Gene sequence |
| |
|
|
