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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TNFRSF13C (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 115650 Official gene symbol TNFRSF13C Full name tumor necrosis factor receptor superfamily, member 13C Aliases ,BAFF-R,BAFFR,CD268,MGC138235, Gene summary B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq] Location Chromosome: 22   Locus: 22q13.1-q13.31 Gene position 42322821 - 42321036  Map Viewer Gene orientation minus Gene size 1786 bp Gene sequence >TNFRSF13C:complement(21711605..21713390):Length=1786 AGCTCAGCCTCAGTCCCCGCAGCTTGTGCGGCGGCGTCGGCACCATGAGGCGAGGGCCCC GGAGCCTGCGGGGCAGGGACGCGCCAGCCCCCACGCCCTGCGTCCCGGCCGAGTGCTTCG ACCTGCTGGTCCGCCACTGCGTGGCCTGCGGGCTCCTGCGCACGCCGCGGCCGAAACCGG GTAAGGGGGACCCACGGGGCGCGCGGCGCCGGCAGCTGCGGGGAGAACGGGGCCCCGATC GCCAGGGCGCAGGCAGAGCCCCGACCCCCGGGGGCGCCGAGGGCTGAAAGGACCCTGTGG GCAGGGCCTGGAGGGGCCCGCGATCACCGCGTGGCCCTCACCGCCGCCTCTCTCCCTCCC CTTGTCCACCGCCCCCCGGCTGTCCCTCCCCTCCCCGGCCAGCCTCGCCCCCCTCCGCCC CTCCCCGTCCCCGCTCCTCCCTCCCCTCGGCCCCCTGGCCTCCCTCCCTGTCCCCTCCCG AAGCAGCCGGGGCCAGCAGCCCTGCGCCCAGGACGGCGCTGCAGCCGCAGGAGTCGGTGG GCGCGGGGGCCGGCGAGGCGGCGCTGCCCCTGCCCGGGCTGCTCTTTGGCGCCCCCGCGC TGCTGGGCCTGGCACTGGTCCTGGCGCTGGTCCTGGTGGGTCTGGTGAGCTGGAGGCGGC GACAGCGGCGGCTTCGCGGCGCGTCCTCCGCAGAGGCCCCCGACGGAGACAAGGACGGTG AGTTCCGTGTGTAGGGGAACCAGTCTGAGCGGGGCGCAGGGGCTGGGGTGTCGGGACGGT CTAGGGGGAGATGCATGGCCCCTGAGGGGGAGAGAAGGGCTTTAAGGGGAAACGGAGACA GAGTGGAAAAGAGTTTGCGCTGAGGAGCTCAGGCTGGGGAGGGAGACATAGTCCTGCCCC TGAGACCCTGGTCGGAGCCAGGAACAGCTCTGCCCTGACAGACCCCAGTGTGAGGAAGAG ACAGGTTGCAGGAAGGGGGCCCCGTCTGAGGGAGGAGTCTGTCCTGCCCTTTGGGAGTCT AACGGAGCTTGGTTCCCCCATAAATCCCTGAAGAGTTTGCCAGACTGAGCCCCAGCTCCC CAACTCCCTGCCCTGCCAGCTCCCCACTGGCCAGGCCTCTGGACTCAGGGTCAGCCAGGT GCCACCCCTCCCCACCCTGCATTGGGCTTCATTTGACGGAGGACTGCCCCTCCAGAGGAG TCTTCTAGGGGAGGGAGGGAAGGCTGTGACTGAGTACGGAGCCTCTACCCCCTCTGCCTG CAGCCCCAGAGCCCCTGGACAAGGTCATCATTCTGTCTCCGGGAATCTCTGATGCCACAG CTCCTGCCTGGCCTCCTCCTGGGGAAGACCCAGGAACCACCCCACCTGGCCACAGTGTCC CTGTGCCAGCCACAGAGCTGGGCTCCACTGAACTGGTGACCACCAAGACGGCCGGCCCTG AGCAACAATAGCAGGGAGCCGGCAGGAGGTGGCCCCTGCCCTCCCTCTGGACCCCCAGCC AGGGGCTTGGAAATCAAATTCAGCTCTTCACTCCAGCATGCACATGCCCTCTTTCTGGGA CCAGGCTAACTCTGCAGAAGCACAGACACTACAGACCACAGCATTCAGCCCCCATGGAGT TTGGTGTGCTTGCCTTTGGCTTCAGACCTCACCATCTTTGACAGCCCTTGAAGGTGGTAG CCCAGCTCCTGTTCCTGTGCCTTCAAAAGGCTGGGGCACTATGAGTAAAAGACCGCTTTT AAAATGGGGAAGGCACCATTAAGCCAAAATGAATCTGAAAAAAGAC OMIM ID 606269