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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CHN2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1124
Official gene symbolCHN2
Full namechimerin (chimaerin) 2
Aliases,ARHGAP3,BCH,MGC138360,RHOGAP3,
Gene summaryThis gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
LocationChromosome: 7   Locus: 7p15.3
Gene position29234121 - 29553944  Map Viewer
Gene orientationplus
Gene size319824 bp
Gene sequence
OMIM ID602857