| Entrez gene ID | | 10636 |
|
| Official gene symbol | | RGS14 |
|
| Full name | | regulator of G-protein signaling 14 |
|
| Aliases | | ,-, |
|
| Gene summary | | This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq] |
|
| Location | | Chromosome: 5 Locus: 5q35.3 |
|
| Gene position | | 176784844 - 176799599 Map Viewer |
|
| Gene orientation | | plus |
|
| Gene size | | 14756 bp |
|
| Gene sequence |
| |
|
|
