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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TOB1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 10140 Official gene symbol TOB1 Full name transducer of ERBB2, 1 Aliases ,APRO6,MGC104792,MGC34446,PIG49,TOB,TROB,TROB1, Gene summary This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells. [provided by RefSeq] Location Chromosome: 17   Locus: 17q21 Gene position 48941413 - 48939584  Map Viewer Gene orientation minus Gene size 1830 bp Gene sequence >TOB1:complement(14213736..14215565):Length=1830 GGGGAGTTGAAACCTAATTTTGTGGCGTAGCAGCTATGCAGCTTGAAATCCAAGTAGCAC TAAATTTTATTATTTCGTATTTGTACAATAAGCTTCCCAGGAGACGTGTCAACATTTTTG GTGAAGAACTTGAAAGACTTCTTAAGAAGAAATATGAAGGGCACTGGTATCCTGAAAAGC CATACAAAGGATCGGGGTTTAGATGTATACACATAGGGGAGAAAGTGGACCCAGTGATTG AACAAGCATCCAAAGAGAGTGGTTTGGACATTGATGATGTTCGTGGCAATCTGCCACAGG ATCTTAGTGTTTGGATCGACCCATTTGAGGTTTCTTACCAAATTGGTGAAAAGGGACCAG TGAAGGTGCTTTACGTGGATGATAATAATGAAAATGGATGTGAGTTGGATAAGGAGATCA AAAACAGCTTTAACCCAGAGGCCCAGGTTTTTATGCCCATAAGTGACCCAGCCTCATCAG TGTCCAGCTCTCCATCGCCTCCTTTTGGTCACTCTGCTGCTGTAAGCCCTACCTTCATGC CCCGGTCCACTCAGCCTTTAACCTTTACCACTGCCACTTTTGCTGCCACCAAGTTCGGCT CTACCAAAATGAAGAATAGTGGCCGTAGCAACAAGGTTGCACGTACTTCTCCCATCAACC TCGGCTTGAATGTGAATGACCTCTTGAAGCAGAAAGCCATCTCTTCCTCAATGCACTCTC TGTATGGGCTTGGCTTGGGTAGCCAGCAGCAGCCACAGCAACAGCAGCAGCCAGCCCAGC CGCCACCGCCACCACCACCACCACAGCAGCAACAACAGCAGAAAACCTCTGCTCTTTCTC CTAATGCCAAGGAATTTATTTTTCCTAATATGCAGGGTCAAGGTAGTAGTACCAATGGAA TGTTCCCAGGTGACAGCCCCCTTAACCTCAGTCCTCTCCAGTACAGTAATGCCTTTGATG TGTTTGCAGCCTATGGAGGCCTCAATGAGAAATCTTTTGTAGATGGCTTGAATTTTAGCT TAAATAACATGCAGTATTCTAACCAGCAATTCCAGCCTGTTATGGCTAACTAAAAAAAAG AAAATGTATCGTACAAGTTAAAATGCACGGGCCCAAGGGGGATTTTTTTTTTCACCTCCT TGAGAATTTTTTTTTTTAAGCTTATAGTAAGGATACATTCAAGCTTGGTTAAAAAAATAA TAATAAAACATGCATCATTTTTCATTTGCCAACCAAGCACAAAGTTATTTTATACTGACT GTATATTTTAAAGTATACTCTCAGATATGGCCTCTTACAGTATTTAAGATATAGCAAGGA CATGGCTGATTTTTTTTTATAAAAATTGGCACTAATAAGTGGGTTTATTGGTCTTTTCTA ATTGTATAATTTAATTTAGTACAAAGTTTGTAAAATATCAGAGGATATATATATATTGTT TCTACGACATGGTATTGCATTTATATCTTTTTACTACAGTGATCTGTGACAGCAGCAGCT TCATGTTGTATTTTTTTTACTGAAATTGTAAAATATCCATCTTAAAGACATCAACTATTC TAAAAATTGTGTACAGGATATTCCTTTAGTGGTGGAATTAAAATGTACGAATACTTGCTT TTTCAAAAAAATGTATTTTCTGTTAAAAGTTTAAAGATTTTTGCTATATATTATGGAAGA AAAATGTAATCGTAAATATTAATTTTGTACCTATATTGTGCAATACTTGAAAAAAACGGT ATAAAAGTATTTTGAGTCAGTGTCTTACATGTTAAGAGGGACTGAAATAGTTTATATTAA GTTTGTATTAAAATTCTTTAAAATTAAAAA OMIM ID 605523