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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for BCL2L10 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 10017 Official gene symbol BCL2L10 Full name BCL2-like 10 (apoptosis facilitator) Aliases ,BCL-B,Boo,Diva,MGC129810,MGC129811, Gene summary The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq] Location Chromosome: 15   Locus: 15q21 Gene position 52404972 - 52401822  Map Viewer Gene orientation minus Gene size 3151 bp Gene sequence >BCL2L10:complement(23192379..23195529):Length=3151 CGGGCCAAGAAAACCAGCGAAGGCCCGGCCCCCCAGCAGAGGCCGGACCATGGTTGACCA GTTGCGGGAGCGCACCACCATGGCCGACCCGCTGCGGGAGCGCACCGAGCTGTTGCTGGC CGACTACCTGGGGTACTGCGCCCGGGAACCCGGCACCCCCGAGCCGGCGCCATCCACGCC CGAGGCCGCCGTGCTGCGCTCCGCGGCCGCCAGGTTACGGCAGATTCACCGGTCCTTTTT CTCCGCCTACCTCGGCTACCCCGGGAACCGCTTCGAGCTGGTGGCGCTGATGGCGGATTC CGTGCTCTCCGACAGCCCCGGCCCCACCTGGGGCAGAGTGGTGACGCTCGTGACCTTCGC AGGGACGCTGCTGGAGAGAGGGCCGCTGGTGACCGCCCGGTGGAAGAAGTGGGGCTTCCA GCCGCGGCTAAAGGAGCAGGAGGGCGACGTCGCCCGGGACTGCCAGCGCCTGGTGGCCTT GCTGAGCTCGCGGCTCATGGGGCAGCACCGCGCCTGGCTGCAGGCTCAGGGCGGCTGGGT GAGCACGCGGCGGACACCGGGACACGGGGCGGGACGGGCAGCCGGGAAGCGCCCACGAGG CTGGCACGGTGAGGAACCCACCGCGCCAGGCCCCTGGAACGAGGTTTCGTGAAAGCAGAA AGGCTCGTTTCAGCGGGCCTGGAACGTTCGCTGTGAAGTCTGGGGTTTCTCCTCCCCTGG CAGAAAGGCCGGCAGAAATCGGCCTTCTTAGACGGCCGTGAACCGTTCCGAAGCAGCTGC GCAGGCTTAGGTCTGCTCACTTGGACCTTGCCCTGGCCTTAGCCGTCGGGGACTTTTAGG GGGGCACCCACGTTAGGTCTGAACGTTTTGCTCCTATAGAAATCCCCAACCAATGAAGTC AGCAATGGCGGGGCCCCAGCCAGGTGGGGTGTTTTTCTCCTTCGCCTATTAAATGCGCCT TTGGAGAGACTCAGACCCATTGATCACAACCCCCTACGCCTCTCAGCCTGGCCAGAGAGG TTGTGGAGTGTGGTGGTCGCCCAGTGGTGGCGCTGACCCAAGGTTCCTTAATTTCTAGTC CTCTGCACCCAGTCCTCGGTGAGAACGTTCTAGGCCCCTGGCTTTCAGCTGCAAGCCTTC ATCTCTGTGGTCAAGGTTAGAGGGACAGGCCCTTGCCCTGCAGCTGATGATCAAGGAAAG CCACCTGGTGATGAGCCCACTGCATGCCTCTGGGGGCTCTGAGCTAGACCCCATTTCTTT CCCCACCACCTTATTGGCGTTGATTCAATGACTGAAGTGGCCCATGTTATCGGATACCTA TAGCCAAACTATTAAAACCAGCAAGTTTTTTGATCCGAAATGTAGCCTCCTGGGGGCAGT TTCCATTTAGACCTTTTTCTTTTTTTCTTTGAGGCGGAGTCTCGCTCTGTGGCCAGGCTG GAGTGCGGTGGTGGATCCCAGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGGATTCTCC TGTCTCAGCCTCCGGAGTAGCTGGGACTACAGGCGCGCCCCACCAAGCCTGGCTAACTGT GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTTCAGTAGAGATGGGCT TTCACCATGTTGGCCAAGATCTCGATCTCTTGATCTCGTGATCTGTCTACCTCAGCCTCC CAAAGTTCTGGGATTACAGACGTGAGCCACCTCACCTGGCCCCCATTTAGACTTTCTATA GTGACAAGTTGGGTTCTATCTGAGAAGGGAAAGGGAGTGGGAGGTGTGTTAGCAGGAACT CCTGCCTTGTTCATAATGTTAGTGTTGGTCTTCAACCCTCTGGGCCGGTGAACTCCCTTC AGCTGCGTGCCTAAGAGCCTCACCTGAGCCCTGTCTCAATACGGCATCTGGCCCCTCCGG GCTCTCTGTACCTGAAGAAGAGATTAGAATTGGAAAGGGGCCGTTGAAGCCTTTTTTTGT TGTTTTTGGCTAATCACTGTTGATGAAAGAATAATCTCTTAACACCAAGGAGCTGAAATT CTTGGCTGGGTGCAGTGGCTCGCACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGT GGATCACCTGAGGCCAGGAGTTCAAGACTAGCCTGACCAACATGGTGAAACCCCCTCTCT ACTAAAAATACAAAATTAGCCAAGCACGGTGGCAGGTGCATGTAATCCCAGCTACTAGGG AGGCTGAGCCAGGAGAATCGCTTGAACCCAGGAGGTGGAGATTGCAGTGAGTTGAGATCT TGCCATTGCACTCCAGCCTGGGCACCAAGAGCGAAACTCTGTCTCAAAAAAAAAAGCTGA AATTCTCAAATTGGGTAAACATAGTTCACCCTTGTCTCTGCCCATTGCAGTTAAAATGCC ACAGCCTGGAGTTCAATTCCCTTCCTAAATGGGGTTGGTGCTTGCTGTAGTGTCAGGTGA TAACTTTTCAATCTAGTGACTTGACAGTTTCCCAAAAGGCATCTCTTCTTTGCTCAGAAA AGAGCATAATAAGCTACCTTCCTCTTGGTTTTGAGTCAAGATATGAGTGTTCCTGCACCA AGTGACAAAGTTAAATGCTTGCTTCTGTTCACTCTGTTAGACTTACCAATCCTCACTCCT CAGGGGCTCCTCATTACTGGATGTGTATTGGTCAGAATTTCCTTTCCTTTTACTTTTTAA ATCCAAACTTTACTTTGCTGTTTAATCTGGAAGTTCCTGCGTGTTTTGAGTGAGGTTCTC AGCATCATGAGGCAATCTAACTTTTCTCTCTCCCCCCTGTAGGATGGCTTTTGTCACTTC TTCAGGACCCCCTTTCCACTGGCTTTTTGGAGAAAACAGCTGGTCCAGGCTTTTCTGTCA TGCTTGTTAACAACAGCCTTCATTTATCTCTGGACACGATTATTATGAGTTTTAAAACTT TTAACCCGCTTCTACCTGCCCAACTGTGACCAACTAAATGACAGATGTGTGAGAACAAGA ACTGAGGGAAAGCACCTTCCCCCACCCCAGACGTTTTTATCTGAATGCATACAAGGAGTC CTGAGGTGGTGATTTGGCCAGTGTTTTAACTTGTGACAAGTACTCAGGTGTGAGGACAAG AATGCAAATGGCTCTTCCTTGAGTGAAAGAA OMIM ID 606910