Interacting Proteins

Macro molecule	Gene	Interacting molecule/ protein	Interacting gene	PDB ID	Title	Structure Title	Experimental Method	Resolution (Å)	PubMed ID	Structure
Replicase polyprotein 1ab	rep, 1a-1b	ADP-HPM	~	6Z72	Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential.	SARS-CoV-2 Macrodomain in complex with ADP-HPM	X-ray diffraction	2.3	33202171	3D view
Replicase polyprotein 1ab	rep, 1a-1b	ADP-HPD	~	6Z6I	Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential.	SARS-CoV-2 Macrodomain in complex with ADP-HPD	X-ray diffraction	2	33202171	3D view
Replicase polyprotein 1ab	rep, 1a-1b	ADP-ribose	~	6Z5T	Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential.	SARS-CoV-2 Macrodomain in complex with ADP-ribose	X-ray diffraction	1.571	33202171	3D view
NSP3 macrodomain	rep, 1a-1b	ADP-ribose	~	6YWL	Crystal structure of SARS-CoV-2 (Covid-19) NSP3 macrodomain in complex with ADP-ribose	Crystal structure of SARS-CoV-2 (Covid-19) NSP3 macrodomain in complex with ADP-ribose	X-ray diffraction	2.5	To be published	3D view
ORF1ab polyprotein	ORF1ab	Uridine 5' monophosphate	~	7K0R	Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15 Reveal Insight into Nuclease Specificity and Dynamics	Nucleotide bound SARS-CoV-2 Nsp15	Electron Microscopy	3.3	To be published	3D view
Uridylate-specific endoribonuclease	rep, 1a-1b	Uridine-3',5'-Diphosphate	~	7K1O	Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-3',5'-Diphosphate	Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-3',5'-Diphosphate	X-ray diffraction	2.4	To be published	3D view
Uridylate-specific endoribonuclease	rep, 1a-1b	Uridine-2',3'-Vanadate	~	7K1L	Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-2',3'-Vanadate	Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-2',3'-Vanadate	X-ray diffraction	2.25	To be published	3D view
Nsp 3 -Macro domain	rep, 1a-1b	ADP-ribose	~	7C33	Structural, Biophysical, and Biochemical Elucidation of the SARS-CoV-2 Nonstructural Protein 3 Macro Domain.	Macro domain of SARS-CoV-2 in complex with ADP-ribose	X-ray diffraction	3.83	32946224	3D view
Macro domain from non-structural protein 3	~	ADP-ribose	~	7CZ4	Structural, Biophysical, and Biochemical Elucidation of the SARS-CoV-2 Nonstructural Protein 3 Macro Domain.	Structure of SARS-CoV-2 macro domain in complex with ADP-ribose	X-ray diffraction	2.64	32946224	3D view
NSP3 macrodomain	rep, 1a-1b	cyclic AMP	~	7JME	Structure of the SARS-CoV-2 NSP3 Macro X domain in complex with cyclic AMP	Structure of the SARS-CoV-2 NSP3 Macro X domain in complex with cyclic AMP	X-ray diffraction	1.55	To be published	3D view
Nsp10, 2'-O-methyltransferase	rep, 1a-1b	Cap-0 and SAM (S-adenosylmethionine )	~	7KOA	Room Temperature Structure of SARS-CoV-2 Nsp10/Nsp16 Methyltransferase in a Complex with Cap-0 and SAM Determined by Pink-Beam Serial Crystallography	Room Temperature Structure of SARS-CoV-2 Nsp10/16 Methyltransferase in a Complex with Cap-0 and SAM Determined by Pink-Beam Serial Crystallography	X-ray diffraction	2.4	To be published	3D view
Nsp3	rep, 1a-1b	ADP-ribose	~	7KQP	Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose (P43 crystal form)	Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose (P43 crystal form)	X-ray diffraction	0.88	To be published	3D view
Non-structural protein 3	rep, 1a-1b	ADP ribose	~	6W02	Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes.	Crystal Structure of ADP ribose phosphatase of NSP3 from SARS CoV-2 in the complex with ADP ribose	X-ray diffraction	1.5	32939273	3D view
Uridylate-specific endoribonuclease	rep, 1a-1b	Citrate	~	6W01	Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2.	The 1.9 A Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with a Citrate	X-ray diffraction	1.9	32304108	3D view
Non-structural protein 3	rep, 1a-1b	AMP	~	6W6Y	Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes.	Crystal Structure of ADP ribose phosphatase of NSP3 from SARS CoV-2 in complex with AMP	X-ray diffraction	1.451	32939273	3D view
Nsp3	rep, 1a-1b	MES (2-(N-morpholino)ethanesulfonic acid)	~	6WCF	Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes.	Crystal Structure of ADP ribose phosphatase of NSP3 from SARS-CoV-2 in complex with MES	X-ray diffraction	1.065	32939273	3D view
2'-O-methyltransferase Nsp10	rep, 1a-1b	S-Adenosyl-L-Homocysteine	~	6WJT	2.0 Angstrom Resolution Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 in Complex with S-Adenosyl-L-Homocysteine	2.0 Angstrom Resolution Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 in Complex with S-Adenosyl-L-Homocysteine	X-ray diffraction	2	To be published	3D view
Uridylate-specific endoribonuclease	rep, 1a-1b	Uridine-5'-Monophosphate	~	6WLC	Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2	Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-5'-Monophosphate	X-ray diffraction	1.82	To be published	3D view
2'-O-methyltransferase Nsp10	rep, 1a-1b	RNA cap analogue (m7GpppA) and S-adenosylmethionine	~	6WKS	Structure of SARS-CoV-2 nsp16/nsp10 ternary complex	Structure of SARS-CoV-2 nsp16/nsp10 in complex with RNA cap analogue (m7GpppA) and S-adenosylmethionine	X-ray diffraction	1.8	To be published	3D view
Nsp3	rep, 1a-1b	ADP-ribose	~	6WOJ	The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase.	Structure of the SARS-CoV-2 macrodomain (NSP3) in complex with ADP-ribose	X-ray diffraction	2.2	33158944	3D view
2'-O-methyltransferase Nsp10	rep, 1a-1b	7-methyl-GpppA and S-adenosyl-L-homocysteine.	~	6WQ3	Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 in Complex with 7-methyl-GpppA and S-adenosyl-L-homocysteine.	Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 in Complex with 7-methyl-GpppA and S-adenosyl-L-homocysteine.	X-ray diffraction	2.1	To be published	3D view
Uridylate-specific endoribonuclease	rep, 1a-1b	3'-uridinemonophosphate	~	6X4I	Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2	Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with 3'-uridinemonophosphate	X-ray diffraction	1.85	To be published	3D view
2'-O-methyltransferase Nsp10	rep, 1a-1b	7-methyl-GpppA and S-adenosyl-L-homocysteine	~	6WRZ	Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 with 7-methyl-GpppA and S-adenosyl-L-homocysteine in the Active Site and Sulfates in the mRNA Binding Groove.	Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 with 7-methyl-GpppA and S-adenosyl-L-homocysteine in the Active Site and Sulfates in the mRNA Binding Groove.	X-ray diffraction	2.25	To be published	3D view
2'-O-methyltransferase Nsp10	rep, 1a-1b	7-methyl-GpppA and S-Adenosylmethionine	~	6WVN	Crystal Structure of Nsp16-Nsp10 from SARS-CoV-2 in Complex with 7-methyl-GpppA and S-Adenosylmethionine.	Crystal Structure of Nsp16-Nsp10 from SARS-CoV-2 in Complex with 7-methyl-GpppA and S-Adenosylmethionine.	X-ray diffraction	2	To be published	3D view

Replicase polyprotein 1ab

rep, 1a-1b

ADP-HPM

~

6Z72

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential.

SARS-CoV-2 Macrodomain in complex with ADP-HPM

X-ray diffraction

2.3

33202171

3D view

Replicase polyprotein 1ab

rep, 1a-1b

ADP-HPD

~

6Z6I

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential.

SARS-CoV-2 Macrodomain in complex with ADP-HPD

X-ray diffraction

2

33202171

3D view

Replicase polyprotein 1ab

rep, 1a-1b

ADP-ribose

~

6Z5T

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential.

SARS-CoV-2 Macrodomain in complex with ADP-ribose

X-ray diffraction

1.571

33202171

3D view

NSP3 macrodomain

rep, 1a-1b

ADP-ribose

~

6YWL

Crystal structure of SARS-CoV-2 (Covid-19) NSP3 macrodomain in complex with ADP-ribose

X-ray diffraction

2.5

To be published

3D view

ORF1ab polyprotein

ORF1ab

Uridine 5' monophosphate

~

7K0R

Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15 Reveal Insight into Nuclease Specificity and Dynamics

Nucleotide bound SARS-CoV-2 Nsp15

Electron Microscopy

3.3

To be published

3D view

Uridylate-specific endoribonuclease

rep, 1a-1b

Uridine-3',5'-Diphosphate

~

7K1O

Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-3',5'-Diphosphate

X-ray diffraction

2.4

To be published

3D view

Uridylate-specific endoribonuclease

rep, 1a-1b

Uridine-2',3'-Vanadate

~

7K1L

Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-2',3'-Vanadate

X-ray diffraction

2.25

To be published

3D view

Nsp 3 -Macro domain

rep, 1a-1b

ADP-ribose

~

7C33

Structural, Biophysical, and Biochemical Elucidation of the SARS-CoV-2 Nonstructural Protein 3 Macro Domain.

Macro domain of SARS-CoV-2 in complex with ADP-ribose

X-ray diffraction

3.83

32946224

3D view

Macro domain from non-structural protein 3

~

ADP-ribose

~

7CZ4

Structural, Biophysical, and Biochemical Elucidation of the SARS-CoV-2 Nonstructural Protein 3 Macro Domain.

Structure of SARS-CoV-2 macro domain in complex with ADP-ribose

X-ray diffraction

2.64

32946224

3D view

NSP3 macrodomain

rep, 1a-1b

cyclic AMP

~

7JME

Structure of the SARS-CoV-2 NSP3 Macro X domain in complex with cyclic AMP

X-ray diffraction

1.55

To be published

3D view

Nsp10, 2'-O-methyltransferase

rep, 1a-1b

Cap-0 and SAM (S-adenosylmethionine )

~

7KOA

Room Temperature Structure of SARS-CoV-2 Nsp10/Nsp16 Methyltransferase in a Complex with Cap-0 and SAM Determined by Pink-Beam Serial Crystallography

Room Temperature Structure of SARS-CoV-2 Nsp10/16 Methyltransferase in a Complex with Cap-0 and SAM Determined by Pink-Beam Serial Crystallography

X-ray diffraction

2.4

To be published

3D view

Nsp3

rep, 1a-1b

ADP-ribose

~

7KQP

Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose (P43 crystal form)

X-ray diffraction

0.88

To be published

3D view

Non-structural protein 3

rep, 1a-1b

ADP ribose

~

6W02

Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes.

Crystal Structure of ADP ribose phosphatase of NSP3 from SARS CoV-2 in the complex with ADP ribose

X-ray diffraction

1.5

32939273

3D view

Uridylate-specific endoribonuclease

rep, 1a-1b

Citrate

~

6W01

Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2.

The 1.9 A Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with a Citrate

X-ray diffraction

1.9

32304108

3D view

Non-structural protein 3

rep, 1a-1b

AMP

~

6W6Y

Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes.

Crystal Structure of ADP ribose phosphatase of NSP3 from SARS CoV-2 in complex with AMP

X-ray diffraction

1.451

32939273

3D view

Nsp3

rep, 1a-1b

MES (2-(N-morpholino)ethanesulfonic acid)

~

6WCF

Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes.

Crystal Structure of ADP ribose phosphatase of NSP3 from SARS-CoV-2 in complex with MES

X-ray diffraction

1.065

32939273

3D view

2'-O-methyltransferase Nsp10

rep, 1a-1b

S-Adenosyl-L-Homocysteine

~

6WJT

2.0 Angstrom Resolution Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 in Complex with S-Adenosyl-L-Homocysteine

X-ray diffraction

2

To be published

3D view

Uridylate-specific endoribonuclease

rep, 1a-1b

Uridine-5'-Monophosphate

~

6WLC

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-5'-Monophosphate

X-ray diffraction

1.82

To be published

3D view

2'-O-methyltransferase Nsp10

rep, 1a-1b

RNA cap analogue (m7GpppA) and S-adenosylmethionine

~

6WKS

Structure of SARS-CoV-2 nsp16/nsp10 ternary complex

Structure of SARS-CoV-2 nsp16/nsp10 in complex with RNA cap analogue (m7GpppA) and S-adenosylmethionine

X-ray diffraction

1.8

To be published

3D view

Nsp3

rep, 1a-1b

ADP-ribose

~

6WOJ

The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase.

Structure of the SARS-CoV-2 macrodomain (NSP3) in complex with ADP-ribose

X-ray diffraction

2.2

33158944

3D view

2'-O-methyltransferase Nsp10

rep, 1a-1b

7-methyl-GpppA and S-adenosyl-L-homocysteine.

~

6WQ3

Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 in Complex with 7-methyl-GpppA and S-adenosyl-L-homocysteine.

X-ray diffraction

2.1

To be published

3D view

Uridylate-specific endoribonuclease

rep, 1a-1b

3'-uridinemonophosphate

~

6X4I

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with 3'-uridinemonophosphate

X-ray diffraction

1.85

To be published

3D view

2'-O-methyltransferase Nsp10

rep, 1a-1b

7-methyl-GpppA and S-adenosyl-L-homocysteine

~

6WRZ

Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 with 7-methyl-GpppA and S-adenosyl-L-homocysteine in the Active Site and Sulfates in the mRNA Binding Groove.

X-ray diffraction

2.25

To be published

3D view

2'-O-methyltransferase Nsp10

rep, 1a-1b

7-methyl-GpppA and S-Adenosylmethionine

~

6WVN

Crystal Structure of Nsp16-Nsp10 from SARS-CoV-2 in Complex with 7-methyl-GpppA and S-Adenosylmethionine.

X-ray diffraction

2

To be published

3D view

Viral protein-Other molecule complex

Last updated: 2021 Apr 19

Total row(s): 24

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