| NSP12, NSP8,NSP7 |
rep, 1a-1b |
RNA (5'-R(P*UP*UP*AP*AP*GP*UP*UP*AP*U)-3')
RNA (5'-R(P*UP*UP*CP*AP*UP*AP*AP*CP*UP*UP*AP*A)-3')
|
~ |
7AAP |
Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP |
Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP |
ELECTRON MICROSCOPY |
2.5 |
To be published |
3D view |
| Nucleoprotein |
N |
10mer ssRNA |
~ |
7ACT |
Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein. |
The SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain in complex with 10mer ssRNA |
SOLUTION NMR |
~ |
33264373 |
3D view |
| Nucleoprotein |
N |
RNA (5'-R(P*CP*AP*CP*UP*GP*AP*C)-3')
RNA (5'-R(P*GP*UP*CP*AP*GP*UP*G)-3') |
~ |
7ACS |
The SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain in complex with 7mer ssRNA |
The SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain in complex with 7mer dsRNA |
SOLUTION NMR |
~ |
33264373 |
3D view |
| Nsp12, Nsp8, Nsp7 |
rep, 1a-1b |
RNA product |
~ |
6YYT |
Structure of replicating SARS-CoV-2 polymerase. |
Structure of replicating SARS-CoV-2 polymerase |
ELECTRON MICROSCOPY |
2.9 |
32438371 |
3D view |
| RNA-directed RNA polymerase, nsp8, nsp7 |
rep, 1a-1b |
RNA (5'-R(*GP*UP*GP*GP*GP*CP*CP*CP*A)-3') |
~ |
6XQB |
Structure of SARS-CoV-2 RdRp/RNA complex at 3.4 Angstroms resolution |
SARS-CoV-2 RdRp/RNA complex |
ELECTRON MICROSCOPY |
3.4 |
To be published |
3D view |
| RNA-directed RNA polymerase, nsp8, nsp7 |
rep, 1a-1b |
RNA (31-MER) |
~ |
7BZF |
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase. |
COVID-19 RNA-dependent RNA polymerase post-translocated catalytic complex |
ELECTRON MICROSCOPY |
3.26 |
32526208 |
3D view |
| Nsp12, Nsp8,NSP7 |
rep, 1a-1b |
Favipiravir
Primer-RNA (5'-R(P*UP*UP*CP*UP*CP*CP*UP*AP*AP*GP*AP*AP*GP*CP*UP*A)-3')
Template-RNA (5'-R(P*AP*CP*UP*AP*GP*CP*UP*UP*CP*UP*UP*AP*GP*GP*AP*GP*AP*A)-3')
|
~ |
7CTT |
Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state. |
Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state. |
ELECTRON MICROSCOPY |
3.2 |
To be published |
3D view |
| Nsp7, Nsp8 , Nsp13, |
rep, 1a-1b |
RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3') |
~ |
7CXN |
Architecture of a SARS-CoV-2 mini replication and transcription complex. |
Architecture of a SARS-CoV-2 mini replication and transcription complex |
ELECTRON MICROSCOPY |
3.84 |
33208736 |
3D view |
| Nsp7, Nsp8 , Nsp12, Nsp13 |
|
RNA (25-MER)
RNA (26-MER)
RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3') |
~ |
7CXM |
Architecture of a SARS-CoV-2 mini replication and transcription complex. |
Architecture of a SARS-CoV-2 mini replication and transcription complex |
ELECTRON MICROSCOPY |
2.9 |
33208736 |
3D view |
| Replicase polyprotein 1ab, Nsp7, Nsp8 |
rep, 1a-1b |
Template |
~ |
7CYQ |
Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. |
Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in cap synthesis |
ELECTRON MICROSCOPY |
2.83 |
33232691 |
3D view |
| Nsp10, 2'-O-methyltransferase |
rep, 1a-1b |
2'-O-methylated m7GpppA Cap-1 and SAH |
~ |
7JHE |
Room Temperature Structure of SARS-CoV-2 Nsp10/Nsp16 Methyltransferase in a Complex with 2'-O-methylated m7GpppA Cap-1 and SAH Determined by Fixed-Target Serial Crystallography |
Room Temperature Structure of SARS-CoV-2 Nsp10/Nsp16 Methyltransferase in a Complex with 2'-O-methylated m7GpppA Cap-1 and SAH Determined by Fixed-Target Serial Crystallography |
X-RAY DIFFRACTION |
2.25 |
To be published |
3D view |
| Nsp10, Nsp16 |
rep, 1a-1b |
Substrates and Products of 2'-O-methylation of the Cap-1 |
~ |
7JIB |
Room Temperature Crystal Structure of Nsp10/Nsp16 from SARS-CoV-2 with Substrates and Products of 2'-O-methylation of the Cap-1 |
Room Temperature Crystal Structure of Nsp10/Nsp16 from SARS-CoV-2 with Substrates and Products of 2'-O-methylation of the Cap-1 |
X-RAY DIFFRACTION |
2.65 |
To be published |
3D view |
| Nsp10 |
rep, 1a-1b |
2'-O-methyltransferase
RNA (5'-D(*(M7G))-R(P*AP*UP*UP*A)-3') |
~ |
7JYY |
Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA)pUpUpApApA (Cap-0) and S-Adenosylmethionine (SAM). |
Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA)pUpUpApApA (Cap-0) and S-Adenosylmethionine (SAM). |
X-RAY DIFFRACTION |
2.05 |
To be published |
3D view |
| Nsp10 |
rep, 1a-1b |
2'-O-methyltransferase
RNA (5'-D(*(M7G))-R(P*(A2M)P*UP*U)-3') |
~ |
7JZ0 |
Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA2m)pUpUpApApA (Cap-1) and S-Adenosyl-L-homocysteine (SAH). |
Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA2m)pUpUpApApA (Cap-1) and S-Adenosyl-L-homocysteine (SAH). |
X-RAY DIFFRACTION |
2.15 |
To be published |
3D view |
| 3C-like proteinase |
rep, 1a-1b |
C-terminal autoprocessing sequence. |
~ |
7KHP |
Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site. |
Acyl-enzyme intermediate structure of SARS-CoV-2 Mpro in complex with its C-terminal autoprocessing sequence. |
X-RAY DIFFRACTION |
1.95 |
33208735 |
3D view |
| Uridylate-specific endoribonuclease |
rep, 1a-1b |
DNA (5'-R(*GP*U)-3') |
~ |
6X1B |
Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2 |
Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with the Product Nucleotide GpU. |
X-RAY DIFFRACTION |
1.97 |
To be published |
3D view |