| Spike glycoprotein |
S, 2 |
Angiotensin-converting enzyme 2 |
ACE2
UNQ868/PRO1885 |
7A98 |
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion. |
SARS-CoV-2 Spike Glycoprotein with 3 ACE2 Bound |
Electron Microscopy |
5.4 |
32942285 |
3D view |
| Spike glycoprotein |
S, 2 |
Angiotensin-converting enzyme 2 |
ACE2
UNQ868/PRO1885 |
7A97 |
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion. |
SARS-CoV-2 Spike Glycoprotein with 2 ACE2 Bound |
Electron Microscopy |
4.4 |
32942285 |
3D view |
| Spike glycoprotein |
S, 2 |
Angiotensin-converting enzyme 2 |
ACE2
UNQ868/PRO1885 |
7A92 |
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion. |
Dissociated S1 domain of SARS-CoV-2 Spike bound to ACE2 (Unmasked Refinement) |
Electron Microscopy |
4.2 |
32942285 |
3D view |
| Spike glycoprotein |
S, 2 |
Angiotensin-converting enzyme 2 |
ACE2
UNQ868/PRO1885 |
7A91 |
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion. |
Dissociated S1 domain of SARS-CoV-2 Spike bound to ACE2 (Non-Uniform Refinement) |
Electron Microscopy |
3.6 |
32942285 |
3D view |
| Spike glycoprotein |
S, 2 |
Angiotensin-converting enzyme 2 |
ACE2
UNQ868/PRO1885 |
7A94 |
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion. |
SARS-CoV-2 Spike Glycoprotein with 1 ACE2 Bound |
Electron Microscopy |
3.9 |
32942285 |
3D view |
| Spike glycoprotein |
S, 2 |
Angiotensin-converting enzyme 2 |
ACE2
UNQ868/PRO1885 |
7A96 |
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion. |
SARS-CoV-2 Spike Glycoprotein with 1 ACE2 Bound and 1 RBD Erect in Anticlockwise Direction |
Electron Microscopy |
4.8 |
32942285 |
3D view |
| Spike glycoprotein |
S, 2 |
Angiotensin-converting enzyme 2 |
ACE2
UNQ868/PRO1885 |
7A95 |
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion. |
SARS-CoV-2 Spike Glycoprotein with 1 ACE2 Bound and 1 RBD Erect in Clockwise Direction |
Electron Microscopy |
4.3 |
32942285 |
3D view |
| nsp1 |
rep, 1a-1b |
CCDC124-80S-eERF1 ribosome complex |
~ |
6ZME |
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. |
SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex |
Electron Microscopy |
3 |
32680882 |
3D view |
| nsp1 |
rep, 1a-1b |
40S ribosomal subunit complex |
~ |
6ZLW |
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. |
SARS-CoV-2 Nsp1 bound to the human 40S ribosomal subunit |
Electron Microscopy |
2.6 |
32680882 |
3D view |
| nsp1 |
rep, 1a-1b |
human CCDC124-80S-EBP1 ribosome complex |
~ |
6ZM7 |
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. |
SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex |
Electron Microscopy |
2.7 |
32680882 |
3D view |
| nsp1 |
rep, 1a-1b |
pre-40S-like ribosome complex |
~ |
6ZMT |
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. |
SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex |
Electron Microscopy |
3 |
32680882 |
3D view |
| nsp1 |
rep, 1a-1b |
pre-40S-like ribosome complex - state 2 |
~ |
6ZN5 |
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. |
SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex - state 2 |
Electron Microscopy |
3.2 |
32680882 |
3D view |
| nsp1 |
rep, 1a-1b |
human LYAR-80S ribosome complex |
~ |
6ZMI |
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. |
SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex |
Electron Microscopy |
2.6 |
32680882 |
3D view |
| nsp1 |
rep, 1a-1b |
LYAR-80S-eEF1a ribosome complex |
~ |
6ZMO |
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. |
SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex |
Electron Microscopy |
3.1 |
32680882 |
3D view |
| nsp1 |
rep, 1a-1b |
40S complex |
~ |
6ZOJ |
SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation. |
SARS-CoV-2-Nsp1-40S complex, composite map |
Electron Microscopy |
2.8 |
32908316 |
3D view |
| nsp1 |
rep, 1a-1b |
40S complex |
~ |
6ZOK |
SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation. |
SARS-CoV-2-Nsp1-40S complex, focused on body |
Electron Microscopy |
2.8 |
32908316 |
3D view |
| nsp1 |
rep, 1a-1b |
human 43S preinitiation ribosome |
~ |
6ZON |
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. |
SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1 |
Electron Microscopy |
3 |
32680882 |
3D view |
| Receptor binding domain |
S,2 |
1.Sodium-dependent neutral amino acid transporter B(0)AT1
2.Angiotensin-converting enzyme 2
|
SLC6A19, B0AT1, ACE2, UNQ868/PRO1885 |
6M17 |
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. |
The 2019-nCoV RBD/ACE2-B0AT1 complex |
Electron Microscopy |
2.9 |
32132184 |
3D view |
| Spike glycoprotein RBD |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2
UNQ868/PRO1885 |
6M0J |
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. |
Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE2 |
X-ray diffraction |
2.45 |
32225176 |
3D view |
| Spike glycoprotein |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2, UNQ868/PRO1885 |
6LZG |
Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2. |
Structure of novel coronavirus spike receptor-binding domain complexed with its receptor ACE2 |
X-ray diffraction |
2.5 |
32275855 |
3D view |
| Spike glycoprotein |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2, UNQ868/PRO1885 |
7DF4 |
Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM. |
SARS-CoV-2 S-ACE2 complex |
Electron Microscopy |
3.8 |
33277323 |
3D view |
| Nsp1 |
rep, 1a-1b |
40S ribosomal complex |
RPSA, RPS3A, RPS28, RPS5, RPS9, RPS13, RPS15, RPS21 |
7JQB |
Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA. |
SARS-CoV-2 Nsp1 and rabbit 40S ribosome complex |
Electron Microscopy |
2.7 |
33188728 |
3D view |
| Nsp1 |
rep, 1a-1b |
40S ribosomal complex |
RPSA, RPS3A, RPS28, RPS5, RPS9, RPS13, RPS15, RPS21 |
7JQC |
Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA. |
SARS-CoV-2 Nsp1, CrPV IRES and rabbit 40S ribosome complex |
Electron Microscopy |
3.3 |
33188728 |
3D view |
| Spike glycoprotein |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2 |
7C8D |
Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2. |
Cryo-EM structure of cat ACE2 and SARS-CoV-2 RBD |
Electron Microscopy |
3 |
33020722 |
3D view |
| Spike glycoprotein |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2, UNQ868/PRO1885 |
7CT5 |
Engineered trimeric ACE2 binds viral spike protein and locks it in "Three-up" conformation to potently inhibit SARS-CoV-2 infection. |
S protein of SARS-CoV-2 in complex bound with T-ACE2 |
Electron Microscopy |
4 |
33177651 |
3D view |
| Spike glycoprotein |
S,2 |
Neuropilin-1 |
NRP1, NRP, VEGF165R |
7JJC |
Neuropilin-1 is a host factor for SARS-CoV-2 infection. |
Crystal structure of neuropilin-1 b1 domain in complex with SARS-CoV-2 S1 C-end rule (CendR) peptide |
X-ray diffraction |
2.36 |
33082294 |
3D view |
| Nsp1 |
|
40S ribosome |
RPS17, RPS17L, RPS29, RPS3, OK/SW-cl.26, RPS5, RPS10, RPS12, RPS15, RIG, RPS16, RPS18, D6S218E, RPS19, RPS20, RPS25, RPS28, RPS27A, UBA80, UBCEP1, RACK1, GNB2L1, HLC7, PIG21, RPSA, LAMBR, LAMR1, RPS3A, FTE1, MFTL, RPS2, RPS4, RPS4X, CCG2, RPS4, SCAR, RPS6, OK/SW-cl.2, RPS7, RPS8, OK/SW-cl.83, RPS9, RPS11, RPS13, RPS14, PRO2640, RPS21, RPS15A, OK/SW-cl.82, RPS23, RPS24, RPS26, RPS27, MPS1, FAU, RPL41, |
7K5I |
SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism. |
SARS-COV-2 nsp1 in complex with human 40S ribosome |
Electron Microscopy |
2.9 |
32995777 |
3D view |
| Orf9b |
9b |
Mitochondrial import receptor subunit TOM70 |
KIAA0719
TOMM70
TOMM70A
|
7KDT |
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. |
Human Tom70 in complex with SARS CoV2 Orf9b |
Electron Microscopy |
3.05 |
33060197 |
3D view |
| Spike glycoprotein |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2, UNQ868/PRO1885 |
7KJ4 |
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro. |
SARS-CoV-2 Spike Glycoprotein with three ACE2 Bound |
Electron Microscopy |
3.4 |
32995768 |
3D view |
| Spike glycoprotein |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2, UNQ868/PRO1885 |
7KJ2 |
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro. |
SARS-CoV-2 Spike Glycoprotein with one ACE2 Bound |
Electron Microscopy |
3.6 |
32995768 |
3D view |
| Spike glycoprotein |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2, UNQ868/PRO1885 |
7KJ3 |
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro. |
SARS-CoV-2 Spike Glycoprotein with two ACE2 Bound |
Electron Microscopy |
3.7 |
32995768 |
3D view |
| Protein 3a |
|
Apolipoprotein A-I |
APOA1 |
7KJR |
Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs. |
Cryo-EM structure of SARS-CoV-2 ORF3a |
Electron Microscopy |
2.08 |
32587976 |
3D view |
| Spike glycoprotein |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2, UNQ868/PRO1885 |
7KMS |
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. |
Cryo-EM structure of triple ACE2-bound SARS-CoV-2 trimer spike at pH 7.4 |
Electron Microscopy |
3.64 |
33271067 |
3D view |
| Spike glycoprotein |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2, UNQ868/PRO1885 |
7KMB |
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. |
ACE2-RBD Focused Refinement Using Symmetry Expansion of Applied C3 for Triple ACE2-bound SARS-CoV-2 Trimer Spike at pH 7.4 |
Electron Microscopy |
3.39 |
33271067 |
3D view |
| Spike glycoprotein |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2, UNQ868/PRO1885 |
7KNE |
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. |
Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 5.5 |
Electron Microscopy |
3.85 |
33271067 |
3D view |
| Spike glycoprotein |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2, UNQ868/PRO1885 |
7KNB |
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. |
Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 7.4 |
Electron Microscopy |
3.93 |
33271067 |
3D view |
| Spike glycoprotein |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2, UNQ868/PRO1885 |
7KNH |
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. |
Cryo-EM Structure of Double ACE2-Bound SARS-CoV-2 Trimer Spike at pH 5.5 |
Electron Microscopy |
3.74 |
33271067 |
3D view |
| Spike glycoprotein |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2, UNQ868/PRO1885 |
7KNI |
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. |
Cryo-EM structure of Triple ACE2-bound SARS-CoV-2 Trimer Spike at pH 5.5 |
Electron Microscopy |
3.91 |
33271067 |
3D view |
| Spike glycoprotein |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2, UNQ868/PRO1885 |
7KMZ |
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. |
Cryo-EM structure of double ACE2-bound SARS-CoV-2 trimer Spike at pH 7.4 |
Electron Microscopy |
3.62 |
33271067 |
3D view |
| SARS-CoV-2 chimeric RBD |
S,2 |
Angiotensin-converting enzyme 2 |
ACE2, UNQ868/PRO1885 |
6VW1 |
Structural basis of receptor recognition by SARS-CoV-2. |
Structure of SARS-CoV-2 chimeric receptor-binding domain complexed with its receptor human ACE2 |
X-ray diffraction |
2.68 |
32225175 |
3D view |