| | SARS-CoV-2 spike-specific CD8+ and CD4+ T cells were detected in 70% and 100% of COVID-19 convalescent cases, respectively. In addition to the M, spike and N protein, CD4+ T cell responses were also seen against ORF3a, ORF8, nsp3, and nsp4 proteins. SARS-CoV-2 RBD-specific IgG and IgA levels correlated with CD4+ T cell responses to spike protein. SARS-CoV-2-reactive CD4+ T cells were also detected in 40%-60% of unexposed individuals suggesting cross-reactive T cell recognition. | "1.) Participant Characteristics: Table 1 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/table/tbl1/?report=objectonly)
2.) SARS-CoV-2 IgM, IgA, and IgG Responses of Recovered COVID-19 Patients: Figure 1 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/figure/fig1/).
3.) SARS-CoV-2-Specific CD4+ T Cell Responses of Recovered COVID-19 Patients: Figure 2 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/figure/fig2/)
4.) SARS-CoV-2-Specific CD8+ T Cell Responses by Recovered COVID-19 Patients: Figure 3 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/figure/fig3/)
5.) Correlations between SARS-CoV-2-Specific CD4+ T Cells, Antibodies, and CD8+ T Cells: Figure 4 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/figure/fig4/)" ✍ | 32473127
(Cell)
| PMID | 32473127 Date of Publishing: 2020 Jun 25 | | Title | Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals | | Author(s) name | Grifoni A, Weiskopf D et al. | | Journal | Cell | | Impact factor | 27.35 Citation count: 1548 | | Date of Entry | 2021 Jul 24 |
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| NLM format |
| Grifoni A, Weiskopf D, Ramirez SI, Mateus J, Dan JM, Moderbacher CR, Rawlings SA, Sutherland A, Premkumar L, Jadi RS, Marrama D, de Silva AM, Frazier A, Carlin AF, Greenbaum JA, Peters B, Krammer F, Smith DM, Crotty S, Sette A. Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals. Cell. 2020 Jun 25;181(7):1489-1501.e15. PMID:32473127 |
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