| | Based on the intermolecular contact maps (COCOMAPS tool) of ACE2-S complex structure, three short peptides (pep1c, pep1d, pep1e) were designed to block virus-host interaction in the early stages of SARS-CoV-2 infection. | New therapeutics for oral administration against SARS-CoV-2 infection can be developed using these peptides, which could be an alternative to traditional drug development. ✍ | 33918595
(Molecules)
| PMID | 33918595 Date of Publishing: 2021 Apr 9 | | Title | Native Structure-Based Peptides as Potential ProteinProtein Interaction Inhibitors of SARS-CoV-2 Spike Protein and Human ACE2 Receptor | | Author(s) name | Odolczyk N, Marzec E et al. | | Journal | Molecules | | Impact factor | 3.01 Citation count: 8 | | Date of Entry | 2021 Aug 12 |
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| NLM format |
| Odolczyk N, Marzec E, Winiewska-Szajewska M, PoznaĆski J, Zielenkiewicz P. Native Structure-Based Peptides as Potential ProteinProtein Interaction Inhibitors of SARS-CoV-2 Spike Protein and Human ACE2 Receptor. Molecules. 2021 Apr 9;26(8):2157. PMID:33918595 |
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Structural characterization of Peptide-bound SARS-CoV-2 Nsp9 RNA-replicase.
| 3C sequence forms β sheet interactions with the N terminus of the protein from the other protomer, as a result N terminal residues move outward by ∼1.6 Ć (residues 610).
The significance of this is yet to be established. ✍ | 32592996
(iScience)
| PMID | 32592996 Date of Publishing: 2020 Jul 24 | | Title | Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9 | | Author(s) name | Littler DR, Gully BS et al. | | Journal | iScience | | Impact factor | 4.447 Citation count: 83 |
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| NLM format |
| Littler DR, Gully BS, Colson RN, Rossjohn J. Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9. iScience. 2020 Jul 24;23(7):101258. PMID:32592996 |
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