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In vitro studies
Last updated: 2021 Aug 23
Total hit(s): 204
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Original Article
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SID 26681509 exhibits considerable cytotoxicity in Huh7 cells
~
✍
33774649
(
Signal Transduct Target Ther
)
PMID
33774649
Date of Publishing
: 2021 Mar 27
Title
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) name
Zhao MM, Yang WL et al.
Journal
Signal Transduct Target Ther
Impact factor
- n/a -
Citation count
: 73
Date of Entry
2021 Aug 23
×
NLM format
Zhao MM, Yang WL, Yang FY, Zhang L, Huang WJ, Hou W, Fan CF, Jin RH, Feng YM, Wang YC, Yang JK. Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. Signal Transduct Target Ther. 2021 Mar 27;6(1):134. PMID:33774649
Amantadine exhibits no cytotoxicity in Huh7cells
Amantadine is a prophylactic agentinfluenza and for Parkinsons disease. It has been reported to suppress the gene transcription of CTSL
✍
33774649
(
Signal Transduct Target Ther
)
PMID
33774649
Date of Publishing
: 2021 Mar 27
Title
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) name
Zhao MM, Yang WL et al.
Journal
Signal Transduct Target Ther
Impact factor
- n/a -
Citation count
: 73
Date of Entry
2021 Aug 23
×
NLM format
Zhao MM, Yang WL, Yang FY, Zhang L, Huang WJ, Hou W, Fan CF, Jin RH, Feng YM, Wang YC, Yang JK. Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. Signal Transduct Target Ther. 2021 Mar 27;6(1):134. PMID:33774649
E64d exhibits no cytotoxicity in Huh7 cells.
~
✍
33774649
(
Signal Transduct Target Ther
)
PMID
33774649
Date of Publishing
: 2021 Mar 27
Title
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) name
Zhao MM, Yang WL et al.
Journal
Signal Transduct Target Ther
Impact factor
- n/a -
Citation count
: 73
Date of Entry
2021 Aug 23
×
NLM format
Zhao MM, Yang WL, Yang FY, Zhang L, Huang WJ, Hou W, Fan CF, Jin RH, Feng YM, Wang YC, Yang JK. Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. Signal Transduct Target Ther. 2021 Mar 27;6(1):134. PMID:33774649
SID 26681509 significantly inhibits SARS-CoV-2 pseudovirus infection in Huh7 cells.
SID 26681509 exhibits cytotoxicity, hence not used for further experiments.
✍
33774649
(
Signal Transduct Target Ther
)
PMID
33774649
Date of Publishing
: 2021 Mar 27
Title
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) name
Zhao MM, Yang WL et al.
Journal
Signal Transduct Target Ther
Impact factor
- n/a -
Citation count
: 73
Date of Entry
2021 Aug 23
×
NLM format
Zhao MM, Yang WL, Yang FY, Zhang L, Huang WJ, Hou W, Fan CF, Jin RH, Feng YM, Wang YC, Yang JK. Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. Signal Transduct Target Ther. 2021 Mar 27;6(1):134. PMID:33774649
Amantadine inhibits SARS-CoV-2 pseudovirus infection in Huh7 cells by reducing the Cathepsin L
(CTSL)
enzyme activity.
Amantadine can be used as a therapeutic.
✍
33774649
(
Signal Transduct Target Ther
)
PMID
33774649
Date of Publishing
: 2021 Mar 27
Title
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) name
Zhao MM, Yang WL et al.
Journal
Signal Transduct Target Ther
Impact factor
- n/a -
Citation count
: 73
Date of Entry
2021 Aug 23
×
NLM format
Zhao MM, Yang WL, Yang FY, Zhang L, Huang WJ, Hou W, Fan CF, Jin RH, Feng YM, Wang YC, Yang JK. Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. Signal Transduct Target Ther. 2021 Mar 27;6(1):134. PMID:33774649
E64d inhibits SARS-CoV-2 pseudovirus infection in Huh7 cells by reducing the Cathepsin L
(CTSL)
enzyme activity.
E64d can be used as a therapeutic as it inhibits CTSL enzyme activity.
✍
33774649
(
Signal Transduct Target Ther
)
PMID
33774649
Date of Publishing
: 2021 Mar 27
Title
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) name
Zhao MM, Yang WL et al.
Journal
Signal Transduct Target Ther
Impact factor
- n/a -
Citation count
: 73
Date of Entry
2021 Aug 23
×
NLM format
Zhao MM, Yang WL, Yang FY, Zhang L, Huang WJ, Hou W, Fan CF, Jin RH, Feng YM, Wang YC, Yang JK. Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. Signal Transduct Target Ther. 2021 Mar 27;6(1):134. PMID:33774649
Cytotoxicity analysis of Astemizole which inhibits the entry of SARS-CoV-2 Spike pseudoviruses into
ACE2-
expressed HEK293T cells by
binding
to the
ACE2
receptor.
Astemizole didn't influence the viability of ACE2 cells significantly. Astemizole can be re-used as a potential drug candidate in anti-coronavirus therapies
✍
33932547
(
Microb Pathog
)
PMID
33932547
Date of Publishing
: 2021 Apr 28
Title
Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro
Author(s) name
Wang X, Lu J et al.
Journal
Microb Pathog
Impact factor
2.64
Citation count
: 2
Date of Entry
2021 Aug 10
×
NLM format
Wang X, Lu J, Ge S, Hou Y, Hu T, Lv Y, Wang C, He H. Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro. Microb Pathog. 2021 Jul;156:104929. PMID:33932547
Antiviral efficacy of Astemizole which inhibits the entry of SARS-CoV-2 Spike pseudoviruses into
ACE2-
expressed HEK293T cells by
binding
to the
ACE2
receptor.
SARS-COV-2 Spike pseudotype virus to enter the ACE2 cells were reduced significantly.
✍
33932547
(
Microb Pathog
)
PMID
33932547
Date of Publishing
: 2021 Apr 28
Title
Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro
Author(s) name
Wang X, Lu J et al.
Journal
Microb Pathog
Impact factor
2.64
Citation count
: 2
Date of Entry
2021 Aug 10
×
NLM format
Wang X, Lu J, Ge S, Hou Y, Hu T, Lv Y, Wang C, He H. Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro. Microb Pathog. 2021 Jul;156:104929. PMID:33932547
A mammalian cell-based assay was used to identify the coronavirus 3CL protease/pro inhibitors that does not require the use of live virus which demonstrated the assays utility that were highly concordant with the results from live virus testing and identified a set of key structural features shared among broadly active 3CLpro inhibitors. The data suggested that the assay could be applicable to other protease families, thus, representing a general platform for viral protease
inhibitor
studies.
Because of the assays breadth and ease of use, it is well suited to form the backbone of a forward-thinking pandemic preparedness strategy. This would not only be capable of addressing the current human coronaviral strains but also provide the biomedical community with a series of high-value chemical leads to perform additional focused chemical optimization. These compounds could be further checked whether they have undergone preclinical testing for human use.
✍
33910954
(
J Virol
)
PMID
33910954
Date of Publishing
: 2021 Apr 28
Title
Inhibitors of Coronavirus 3CL Proteases Protect Cells from Protease-Mediated Cytotoxicity
Author(s) name
Resnick SJ, Iketani S et al.
Journal
J Virol
Impact factor
4.16
Citation count
: 8
Date of Entry
2021 Aug 10
×
NLM format
Resnick SJ, Iketani S, Hong SJ, Zask A, Liu H, Kim S, Melore S, Lin FY, Nair MS, Huang Y, Lee S, Tay NES, Rovis T, Yang HW, Xing L, Stockwell BR, Ho DD, Chavez A. Inhibitors of Coronavirus 3CL Proteases Protect Cells from Protease-Mediated Cytotoxicity. J Virol. 2021 Jun 24;95(14):e0237420. PMID:33910954
Type I PRMT
inhibitor
(MS023) inhibits interaction of
N
protein with the 5-UTR of SARS-CoV-2 genomic
RNA,
a property required for viral packaging.
PRMT inhibitors, cancer drug canditates, have found to methylate arginine in the N protein, thereby regulating the SARS-CoV-2 lifecycle.
✍
34029587
(
J Biol Chem
)
PMID
34029587
Date of Publishing
: 2021 May 23
Title
Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication
Author(s) name
Cai T, Yu Z et al.
Journal
J Biol Chem
Impact factor
3.96
Citation count
: 11
Date of Entry
2021 Jul 28
×
NLM format
Cai T, Yu Z, Wang Z, Liang C, Richard S. Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication. J Biol Chem. 2021 May 23;297(1):100821. PMID:34029587
Anti-viral activity of six drugs (arbidol, baloxavir, laninamivir, oseltamivir, peramivir, and zanamivir) against SARS-Co-V-2 was tested and among them only arbidol compound demonstrated to efficiently inhibit the virus infection in vitro.
Further clinical studies on Arbidol should be done to check its efficacy and validate the recommended dosage to treat COVID-19 patients.
✍
32373347
(
Cell Discov
)
PMID
32373347
Date of Publishing
: 2020
Title
The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro
Author(s) name
Wang X, Cao R et al.
Journal
Cell Discov
Impact factor
4.65
Citation count
: 122
Date of Entry
2021 Jun 15
×
NLM format
Wang X, Cao R, Zhang H, Liu J, Xu M, Hu H, Li Y, Zhao L, Li W, Sun X, Yang X, Shi Z, Deng F, Hu Z, Zhong W, Wang M. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 2020 May 2;6:28. PMID:32373347
In vitro activity of three Abl tyrosine kinase inhibitors- nilotinib, imatinib and dasatinib against SARS-CoV-2 was analysed in Vero-E6 and Calu-3 cells.
The combinational therapy using antiviral and anti-inflammatory drugs is found to be one of the effective strategy to combat SARS-CoV-2.
✍
33232578
(
Basic Clin Pharmacol Toxicol
)
PMID
33232578
Date of Publishing
: 2020 Nov 24
Title
The tyrosine kinase inhibitor nilotinib inhibits SARS-CoV-2 in vitro
Author(s) name
Cagno V, Magliocco G et al.
Journal
Basic Clin Pharmacol Toxicol
Impact factor
2.29
Citation count
: 14
×
NLM format
Cagno V, Magliocco G, Tapparel C, Daali Y. The tyrosine kinase inhibitor nilotinib inhibits SARS-CoV-2 in vitro. Basic Clin Pharmacol Toxicol. 2021 Apr;128(4):621-624. PMID:33232578
Antiviral activity of Naringenin against SARS-CoV-2
250 and 62.5 micromolar concentrations of Naringenin were very effective in protecting cells from SARS-CoV-2 infection.
✍
33096221
(
Pharmacol Res
)
PMID
33096221
Date of Publishing
: 2020 Oct 20
Title
Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro
Author(s) name
Clementi N, Scagnolari C et al.
Journal
Pharmacol Res
Impact factor
5.78
Citation count
: 31
×
NLM format
Clementi N, Scagnolari C, D'Amore A, Palombi F, Criscuolo E, Frasca F, Pierangeli A, Mancini N, Antonelli G, Clementi M, Carpaneto A, Filippini A. Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro. Pharmacol Res. 2021 Jan;163:105255. PMID:33096221
Invitro studies of chlorpheniramine shows strong virucidal effect against SARS-CoV-2 infected Vero cell line.
CPM's antivirial and anti-inflammatory effects , with minimal side effects could be used in the early treatment and prevention of viral infections like influenzaA/B and COVID-19.
✍
32963923
(
Cureus
)
PMID
32963923
Date of Publishing
: 2020 Sep 17
Title
In Vitro Virucidal Effect of Intranasally Delivered Chlorpheniramine Maleate Compound Against Severe Acute Respiratory Syndrome Coronavirus 2
Author(s) name
Westover JB, Ferrer G et al.
Journal
Cureus
Impact factor
- n/a -
Citation count
: 9
×
NLM format
Westover JB, Ferrer G, Vazquez H, Bethencourt-Mirabal A, Go CC. In Vitro Virucidal Effect of Intranasally Delivered Chlorpheniramine Maleate Compound Against Severe Acute Respiratory Syndrome Coronavirus 2. Cureus. 2020 Sep 17;12(9):e10501. PMID:32963923
Oxyclozanide showed unchanged IC50 (fold change approximately 1) in Calu-3 cells compared to Vero cells.
Oxyclozanide showed IC50 of 3.71 micromolar un Vero cells
✍
32767684
(
J Med Virol
)
PMID
32767684
Date of Publishing
: 2020 Aug 7
Title
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) name
Ko M, Jeon S et al.
Journal
J Med Virol
Impact factor
2.07
Citation count
: 40
×
NLM format
Ko M, Jeon S, Ryu WS, Kim S. Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells. J Med Virol. 2021 Mar;93(3):1403-1408. PMID:32767684
Ivacaftor showed unchanged IC50 (fold change approximately 1) in Calu-3 cells compared to Vero cells.
Ivacaftor showed IC50 of 6.57 micromolar un Vero cells
✍
32767684
(
J Med Virol
)
PMID
32767684
Date of Publishing
: 2020 Aug 7
Title
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) name
Ko M, Jeon S et al.
Journal
J Med Virol
Impact factor
2.07
Citation count
: 40
×
NLM format
Ko M, Jeon S, Ryu WS, Kim S. Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells. J Med Virol. 2021 Mar;93(3):1403-1408. PMID:32767684
Proscillaridin showed increased IC50 (by >2 fold change) in Calu-3 cells compared to Vero cells.
Proscillaridin showed IC50 of 2.04 micromolar in Vero cells
✍
32767684
(
J Med Virol
)
PMID
32767684
Date of Publishing
: 2020 Aug 7
Title
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) name
Ko M, Jeon S et al.
Journal
J Med Virol
Impact factor
2.07
Citation count
: 40
×
NLM format
Ko M, Jeon S, Ryu WS, Kim S. Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells. J Med Virol. 2021 Mar;93(3):1403-1408. PMID:32767684
Tetrandrine showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells.
Tetrandrine showed IC50 of 3 micromolar in Vero cells
✍
32767684
(
J Med Virol
)
PMID
32767684
Date of Publishing
: 2020 Aug 7
Title
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) name
Ko M, Jeon S et al.
Journal
J Med Virol
Impact factor
2.07
Citation count
: 40
×
NLM format
Ko M, Jeon S, Ryu WS, Kim S. Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells. J Med Virol. 2021 Mar;93(3):1403-1408. PMID:32767684
Berbamine hydrochloride showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells.
Berbamine hydrochloride IC50 of 7.87 micromolar in Vero cells
✍
32767684
(
J Med Virol
)
PMID
32767684
Date of Publishing
: 2020 Aug 7
Title
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) name
Ko M, Jeon S et al.
Journal
J Med Virol
Impact factor
2.07
Citation count
: 40
×
NLM format
Ko M, Jeon S, Ryu WS, Kim S. Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells. J Med Virol. 2021 Mar;93(3):1403-1408. PMID:32767684
Abemaciclib showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells.
Abemaciclib showed IC50 of 6.62 micromolar in Vero cells
✍
32767684
(
J Med Virol
)
PMID
32767684
Date of Publishing
: 2020 Aug 7
Title
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) name
Ko M, Jeon S et al.
Journal
J Med Virol
Impact factor
2.07
Citation count
: 40
×
NLM format
Ko M, Jeon S, Ryu WS, Kim S. Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells. J Med Virol. 2021 Mar;93(3):1403-1408. PMID:32767684
Cepharanthine showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells.
Cepharanthine showed IC50 of 4.47 micromolar in Vero cells
✍
32767684
(
J Med Virol
)
PMID
32767684
Date of Publishing
: 2020 Aug 7
Title
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) name
Ko M, Jeon S et al.
Journal
J Med Virol
Impact factor
2.07
Citation count
: 40
×
NLM format
Ko M, Jeon S, Ryu WS, Kim S. Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells. J Med Virol. 2021 Mar;93(3):1403-1408. PMID:32767684
Ciclesonide showed increased IC50 (by >2 fold change) in Calu-3 cells compared to Vero cells.
Ciclesonide showed IC50 of 4.33 micromolar in Vero cells
✍
32767684
(
J Med Virol
)
PMID
32767684
Date of Publishing
: 2020 Aug 7
Title
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) name
Ko M, Jeon S et al.
Journal
J Med Virol
Impact factor
2.07
Citation count
: 40
×
NLM format
Ko M, Jeon S, Ryu WS, Kim S. Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells. J Med Virol. 2021 Mar;93(3):1403-1408. PMID:32767684
Salinomycin sodium showed increased IC50 (by >2 fold change) in Calu-3 cells compared to Vero cells.
Salinomycin sodium IC50 of 0.24 micromolar in Vero cells
✍
32767684
(
J Med Virol
)
PMID
32767684
Date of Publishing
: 2020 Aug 7
Title
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) name
Ko M, Jeon S et al.
Journal
J Med Virol
Impact factor
2.07
Citation count
: 40
×
NLM format
Ko M, Jeon S, Ryu WS, Kim S. Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells. J Med Virol. 2021 Mar;93(3):1403-1408. PMID:32767684
Mefloquine showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells.
Mefloquine showed IC50 of 4.33 micromolar in Vero cells
✍
32767684
(
J Med Virol
)
PMID
32767684
Date of Publishing
: 2020 Aug 7
Title
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) name
Ko M, Jeon S et al.
Journal
J Med Virol
Impact factor
2.07
Citation count
: 40
×
NLM format
Ko M, Jeon S, Ryu WS, Kim S. Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells. J Med Virol. 2021 Mar;93(3):1403-1408. PMID:32767684
Lopinavir
showed increased IC50 (by >2 fold change) in Calu-3 cells compared to Vero cells.
Lopinavir showed IC50 of 9.12 micromolar in Vero cells
✍
32767684
(
J Med Virol
)
PMID
32767684
Date of Publishing
: 2020 Aug 7
Title
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) name
Ko M, Jeon S et al.
Journal
J Med Virol
Impact factor
2.07
Citation count
: 40
×
NLM format
Ko M, Jeon S, Ryu WS, Kim S. Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells. J Med Virol. 2021 Mar;93(3):1403-1408. PMID:32767684