COVID-KOSHA
Home
Help
(current)
!
Note: Language translations may be imperfect
A model anti-pandemic portal for scientists & public
Cytotoxicity
Last updated: 2022 Jul 13
Total hit(s): 87
---Sort by---
Key findings ▲
Key findings ▼
Date of publishing ▲
Date of publishing ▼
Citation Count ▲
Citation Count ▼
Impact Factor ▲
Impact Factor ▼
Select item(s)
Key Findings
Comments
(You can add your comments too!)
Original Article
(hover to see details)
The half-cytotoxic concentration (CC
50
) of Oridonin in Vero E6 cells is 24.94 µm. The selectivity index value is >5 for Oridonin.
The cell-based antiviral results indicate that Oridonin prevents the replication of SARS-CoV-2 via inhibition of 3CLpro.
✍
35600064
(
)
PMID
35600064
Title
Oridonin Inhibits SARS-CoV-2 by Targeting Its 3C-Like Protease
Impact factor
N/A
Date of Entry
2022 Jul 13
×
NLM format
Oridonin Inhibits SARS-CoV-2 by Targeting Its 3C-Like Protease. . . PMID:35600064
SID 26681509 exhibits considerable cytotoxicity in Huh7 cells
~
✍
33774649
(
Signal Transduct Target Ther
)
PMID
33774649
Date of Publishing
: 2021 Mar 27
Title
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) name
Zhao MM, Yang WL et al.
Journal
Signal Transduct Target Ther
Impact factor
- n/a -
Citation count
: 73
Date of Entry
2021 Aug 23
×
NLM format
Zhao MM, Yang WL, Yang FY, Zhang L, Huang WJ, Hou W, Fan CF, Jin RH, Feng YM, Wang YC, Yang JK. Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. Signal Transduct Target Ther. 2021 Mar 27;6(1):134. PMID:33774649
Amantadine exhibits no cytotoxicity in Huh7cells
Amantadine is a prophylactic agentinfluenza and for Parkinsons disease. It has been reported to suppress the gene transcription of CTSL
✍
33774649
(
Signal Transduct Target Ther
)
PMID
33774649
Date of Publishing
: 2021 Mar 27
Title
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) name
Zhao MM, Yang WL et al.
Journal
Signal Transduct Target Ther
Impact factor
- n/a -
Citation count
: 73
Date of Entry
2021 Aug 23
×
NLM format
Zhao MM, Yang WL, Yang FY, Zhang L, Huang WJ, Hou W, Fan CF, Jin RH, Feng YM, Wang YC, Yang JK. Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. Signal Transduct Target Ther. 2021 Mar 27;6(1):134. PMID:33774649
E64d exhibits no cytotoxicity in Huh7 cells.
~
✍
33774649
(
Signal Transduct Target Ther
)
PMID
33774649
Date of Publishing
: 2021 Mar 27
Title
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) name
Zhao MM, Yang WL et al.
Journal
Signal Transduct Target Ther
Impact factor
- n/a -
Citation count
: 73
Date of Entry
2021 Aug 23
×
NLM format
Zhao MM, Yang WL, Yang FY, Zhang L, Huang WJ, Hou W, Fan CF, Jin RH, Feng YM, Wang YC, Yang JK. Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. Signal Transduct Target Ther. 2021 Mar 27;6(1):134. PMID:33774649
Cytotoxicity analysis of Astemizole which inhibits the entry of SARS-CoV-2 Spike pseudoviruses into
ACE2-
expressed HEK293T cells by
binding
to the
ACE2
receptor.
Astemizole didn't influence the viability of ACE2 cells significantly. Astemizole can be re-used as a potential drug candidate in anti-coronavirus therapies
✍
33932547
(
Microb Pathog
)
PMID
33932547
Date of Publishing
: 2021 Apr 28
Title
Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro
Author(s) name
Wang X, Lu J et al.
Journal
Microb Pathog
Impact factor
2.64
Citation count
: 2
Date of Entry
2021 Aug 10
×
NLM format
Wang X, Lu J, Ge S, Hou Y, Hu T, Lv Y, Wang C, He H. Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro. Microb Pathog. 2021 Jul;156:104929. PMID:33932547
Auranofin inhibited SARS-CoV-2 replication in Huh7 cells at CC50 5.7 micromolars.
✍
32442105
(
Virology
)
PMID
32442105
Date of Publishing
: 2020 Aug
Title
The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells
Author(s) name
Rothan HA, Stone S et al.
Journal
Virology
Impact factor
2.819
Citation count
: 54
×
NLM format
Rothan HA, Stone S, Natekar J, Kumari P, Arora K, Kumar M. The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells. Virology. 2020 Aug;547:7-11. PMID:32442105
Cytotoxicity concentration of thioridazine hydrochloride in Vero cells was ~16 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Cytotoxicity concentration of mefloquine in Vero cells was ~14 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Based on the cytopathic effect of the virus,
chloroquine
showed antiviral activity against SARS-CoV-2 at CC50 >37.5 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Based on the cytopathic effect of the virus,
lopinavir
showed antiviral activity against SARS-CoV-2 at CC50 >50 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Based on the cytopathic effect of the virus,
remdesivir
showed antiviral activity against SARS-CoV-2 at CC50 >50 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Based on the cytopathic effect of the virus,
favipiravir
showed antiviral activity against SARS-CoV-2 at CC50 >500 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Based on the cytopathic effect of the virus, atazanavir showed antiviral activity against SARS-CoV-2 at CC50 >50 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Cytotoxicity concentration of Triparanol in Vero cells was ~15 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Cytotoxicity concentration of proscillaridin in Vero cells was >50 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Cytotoxicity concentration of phenazopyridine hydrochloride in Vero cells was >50 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Cytotoxicity concentration of perhexiline maleate in Vero cells was ~9 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Cytotoxicity concentration of penfluridol in Vero cells was ~9 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Cytotoxicity concentration of oxyclozanide in Vero cells was >50 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Cytotoxicity concentration of ouabain in Vero cells was >50 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Cytotoxicity concentration of osimertinib mesylate in Vero cells was ~13 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Cytotoxicity concentration of osajin in Vero cells was ~11 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Cytotoxicity concentration of niclosamide in Vero cells was >50 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Cytotoxicity concentration of mequitazine in Vero cells was ~27 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720
Cytotoxicity concentration of salinomycin sodium in Vero cells was >50 micromolars.
✍
32366720
(
Antimicrob Agents Chemother
)
PMID
32366720
Date of Publishing
: 2020 Jun 23
Title
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) name
Jeon S, Ko M et al.
Journal
Antimicrob Agents Chemother
Impact factor
4.68
Citation count
: 295
×
NLM format
Jeon S, Ko M, Lee J, Choi I, Byun SY, Park S, Shum D, Kim S. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20. PMID:32366720