Clinical features

Last updated: 2022 Aug 26
Total hit(s): 92
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Original Article
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In ten cases, bronchopneumonia was superimposed. Alveolar haemorrhage (n = 3), vasculitis (n = 1), and pulmonary embolism (n = 4) were additional findings. Pathologies in other organ systems were primarily shock-related; five individuals had pulmonary thrombotic microangiopathy, and three patients had generalised microangiopathy. At autopsy, senile cardiac amyloidosis was identified in six cases. The tolerance threshold for COVID-19 may be lower in hypertensive, aged, obese, males with severe cardiovascular comorbidities, and blood group A patients.
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 		32364264
(Histopathology)
PMID
32364264
Date of Publishing: 2020 Aug
Title Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction
Author(s) nameMenter T, Haslbauer JD et al.
Journal Histopathology
Impact factor
3.46
Citation count: 567
Date of Entry 2022 Aug 26

The median CT score was 5, and the median number of zones implicated was five, both of which advanced quickly, peaked over sickness days 611, and then persisted at high levels. Ground-glass opacity was the most common pattern of abnormalities after the onset of symptoms (35 of 78 scans [45% ] to 49 of 79 scans [62% ] in different periods). The proportion of mixed patterns reached its highest on illness days 1217 (30 of 78 scans [38%]), and it thereafter moved into the position of second-most predominating pattern. The most common type of ground-glass opacity after the onset of symptoms was pure ground-glass opacity (20 of 50 scans [40% ] to 20 of 28 scans [71%]).
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 		32191587
(Radiology)
PMID
32191587
Date of Publishing: 2020 Aug
Title Temporal Changes of CT Findings in 90 Patients with COVID-19 Pneumonia: A Longitudinal Study
Author(s) nameWang Y, Dong C et al.
Journal Radiology
Impact factor
7.11
Citation count: 402
Date of Entry 2022 Aug 26

It was reported that Covid-19 which causes severe acute respiratory syndrome, was found in neural and capillary endothelial cells in frontal lobe tissue from a patient (SARS-CoV-2). Our discoveries of the virus in brain tissue, along with the clinical correlations of deteriorating neurologic symptoms, open the door to a deeper comprehension of the pathogenic mechanisms underpinning SARS-involvement CoV-2's in the central nervous system. The findings offer the first proof of the direct spread and presence of SARS-CoV-2 in human brain tissue. Hematogenous dissemination and brain capillary endothelial cells of the brain-blood barrier are thought to facilitate pathogen entry into the central nervous system (CNS) and the subsequent virus-induced neuropathic effects in SARS-CoV-2-infected individuals.
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 		32314810
(J Med Virol)
PMID
32314810
Date of Publishing: 2020 Jul
Title Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
Author(s) namePaniz-Mondolfi A, Bryce C et al.
Journal J Med Virol
Impact factor
2.07
Citation count: 383
Date of Entry 2022 Aug 26

The existence of thrombosis and microangiopathy in the lungs' small blood arteries and capillaries, together with an accompanying haemorrhage, are noteworthy discoveries. This greatly led to the patient's mortality. Even in patients who had not been ventilated, characteristics of diffuse alveolar injury, such as hyaline membranes, were present. Cardiac Individual cell necrosis without lymphocytic myocarditis was seen.
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 		32473124
(Lancet Respir Med)
PMID
32473124
Date of Publishing: 2020 Jul
Title Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans
Author(s) nameFox SE, Akmatbekov A et al.
Journal Lancet Respir Med
Impact factor
15.78
Citation count: 581
Date of Entry 2022 Aug 26

Patients between the ages of 21 and 50 made up the majority (70.2%) of the group. Fever was the primary presenting symptom in the majority of patients (78.2%). Ground-glass opacities (GGO) (87 [86.1%]) or mixed GGO and consolidation (65 [64.4%]), vascular enlargement in the lesion (72 [71.3%]), and traction bronchiectasis were common imaging findings in the majority of patients with COVID-19 pneumonia (53 [52.5%]). Lesions seen on CT scans were more likely to be lower lung predominate (55 [54.5%]) and multifocal (88 [87.1%]), have a peripheral distribution, and include both hemispheres (83 [82.2%]) (55 [54.5% ]). The emergency patients were older than the non-emergency patients. Evaluation of the severity and scope of the disease was improved by the use of architectural distortion, traction bronchiectasis, and the CT involvement score.
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 		32125873
(AJR Am J Roentgenol)
PMID
32125873
Date of Publishing: 2020 May
Title Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2
Author(s) nameZhao W, Zhong Z et al.
Journal AJR Am J Roentgenol
Impact factor
3.19
Citation count: 481
Date of Entry 2022 Aug 26

The progression from pneumonia to ARDS varied from 3% to 63%. These key estimates were highly associated with the case fatality rates reported for each country with a statistically significant positive relationship
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 		33743372
(J Infect Public Health)
PMID
33743372
Date of Publishing: 2021 Apr
Title Progression from Pneumonia to ARDS as a Predictor for Fatal COVID-19
Author(s) nameHsu CY, Lai CC et al.
Journal J Infect Public Health
Impact factor
2.49
Citation count: 9
Date of Entry 2022 Jun 20

The airways of severe COVID-19 patients clogged with MUC5AC-containing mucus show hyperplasia of goblet cells, hypoplasia of multiciliated cells, and hypoplasia of club cells, as well as considerably lower CC16 and MUC5B levels and higher IL-13 levels.
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 		33829055
(ERJ Open Res)
PMID
33829055
Date of Publishing: 2021 Apr
Title Analysis of pathological changes in the epithelium in COVID-19 patient airways
Author(s) nameYin W, Cao W et al.
Journal ERJ Open Res
Impact factor
3.35
Citation count: 5
Date of Entry 2022 Jun 20

This observed incident of secondary fungal infection in a SARS-CoV-2 infected patient is uncommon due to the presence of A. fumigatus and a Mucorales species. Despite antibiotic therapy, the patient felt feverish while in aplasia, and a fresh SARS-CoV-2 RTPCR test from a nasopharyngeal swab revealed a very high respiratory virus load.
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 		33527098
(Infect Dis Now)
PMID
33527098
Date of Publishing: 2021 Jan 27
Title Mixed mold infection with Aspergillus fumigatus and Rhizopus microsporus in a severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) patient
Author(s) nameBellanger AP, Navellou JC et al.
Journal Infect Dis Now
Impact factor
- n/a -
Citation count: 34
Date of Entry 2022 Jun 20

The findings of this group of COVID-19 patients do not suggest acute DIC, but rather hypercoagulability combined with a severe inflammatory condition. These findings could explain why some of these individuals had venous thromboembolism and support antithrombotic prophylaxis and treatment.
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 		32302438
(J Thromb Haemost)
PMID
32302438
Date of Publishing: 2020 Jul
Title Hypercoagulability of COVID-19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis
Author(s) namePanigada M, Bottino N et al.
Journal J Thromb Haemost
Impact factor
4.45
Citation count: 587
Date of Entry 2022 Jun 20

This case highlights the need of considering that thrombocytopenia in SARS-CoV-2 patients, the majority of whom are given heparinoids, could constitute an undiagnosed HIT.
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 		32905282
(Thromb J)
PMID
32905282
Date of Publishing: 2020
Title SARS-CoV-2 and pulmonary embolism: who stole the platelets?
Author(s) nameTran M, Sheth C et al.
Journal Thromb J
Impact factor
2.57
Citation count: 5
Date of Entry 2022 Jun 20

Serial pulmonary function, exercise capacity, and chest high-resolution CT (HRCT) changes in non-intubated patients hospitalised with severe COVID-19 pneumonia are reported in this study at 3 months, 6 months, 9 months, and 12 months after hospital discharge. Despite the fact that most patients' exercise ability improved over time, evidence of persisting physiological and radiographic alterations in a subset of individuals was discovered. No patient had a history of comorbidities or smoking.Pulmonary function tests were done according to American Thoracic Society (ATS)European Respiratory Society guidelines.Patients underwent chest non-contrast enhanced CT examinations in the supine position and with breath-holding following inspiration.6MWD test was done according to the ATS practical guidelines.The severity of dyspnoea was measured using an mMRC scale.
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 		33964245
(Lancet Respir Med)
PMID
33964245
Date of Publishing: 2021 May 5
Title 3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study
Author(s) nameWu X, Liu X et al.
Journal Lancet Respir Med
Impact factor
15.78
Citation count: 105
Date of Entry 2021 Dec 15

Higher in-hospital mortality was linked to both greater Blood urea nitrogen (BUN) upon admission and increased BUN within the first 24 hours. COVID-19 infected patients were found to have an increase in BUN at 24 hours of hospitalization, linked to a composite of clinical outcomes and in-hospital mortality.
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 		33583325
(Ren Fail)
PMID
33583325
Date of Publishing: 2021 Dec
Title Association between an increase in blood urea nitrogen at 24h and worse outcomes in COVID-19 pneumonia
Author(s) nameYe B, Deng H et al.
Journal Ren Fail
Impact factor
1.68
Citation count: 3
Date of Entry 2021 Nov 1

Covid-19 infected patients were analyzed for Pulmonary embolism(PE) and D-dimer levels. Highest frequency of PE was found in ICU patients, most commonly in the peripheral region. Moreover, D-dimer value was higher in Covid-19 infected PE patients.
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 		33966132
(Eur Radiol)
PMID
33966132
Date of Publishing: 2021 May 9
Title Pulmonary embolism in patients with COVID-19 and value of D-dimer assessment: a meta analysis.
Author(s) name Kwee RM, Adams HJA, Kwee TC.
Journal Eur Radiol
Impact factor
3.11
Citation count: 8
Date of Entry 2021 Nov 1

Lung ultrasound and Computed Tomography (CT) were compared to check their ability to diagnose COVID-19. Although Lung Ultra sound (LUS) could diagnose COVID-19 there was only a moderate correlation with CT findings as for lesion patterns and severity quantification 145 patients(66%) had pre-existing pathologies including cardiovascular diseases, active neoplastic disease and chronic kidney disease.
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 		33743491
(Eur J Radiol)
PMID
33743491
Date of Publishing: 2021 May
Title Correlation between lung ultrasound and chest CT patterns with estimation of pulmonary burden in COVID-19 patients
Author(s) nameRizzetto F, Perillo N et al.
Journal Eur J Radiol
Impact factor
3.11
Citation count: 4
Date of Entry 2021 Nov 1

In non-critical COVID-19 patients, a blockage in the pulmonary (lung) artery was detected on Computer Tomography Pulmonary Angiography (CTPA). Daignostic tools such as D-dimer levels were not useful in precticitng the presence of Acute pulmonary embolism (APE). Heparin was used as an anticoagulant in 73% patients before conducting the Computer Tomography Pulmonary Angiography(CTPA).
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 		33834578
(Intern Med J)
PMID
33834578
Date of Publishing: 2021 Apr 8
Title Acute pulmonary embolism in patients presenting pulmonary deterioration after hospitalisation for non-critical Covid-19.
Author(s) namePolo Friz H, Gelfi E et al.
Journal Intern Med J
Impact factor
1.75
Citation count: 2
Date of Entry 2021 Nov 1

The incidence of Deep vein thrombosis(DVT) and Pulmonary embolism(PE) was significantly higher in hopsialized COVID-19 patients when compared to non-COVID-19 individuals. Patients with DVT and PE had comparatively higher mortality rate, longer hospital stay and ICU when compared to the non-infected patients.
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 		33836287
(J Vasc Surg Venous Lymphat Disord)
PMID
33836287
Date of Publishing: 2021 Apr 6
Title Deep vein thrombosis and pulmonary embolism among hospitalized coronavirus disease 2019- positive patients predicted for higher mortality and prolonged intensive care unit and hospital stays in a multisite healthcare system.
Author(s) nameErben Y, Franco-Mesa C et al.
Journal J Vasc Surg Venous Lymphat Disord
Impact factor
2.11
Citation count: 6
Date of Entry 2021 Nov 1

Patients with pleural complications of Covid-19 pneumonia have a very high death rate. In critically ill patients with COVID-19 pneumonia, pneumothorax is a serious event.
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 		33890447
(Turk J Med Sci)
PMID
33890447
Date of Publishing: 2021 Apr 23
Title The analysis of pleural complications of COVID-19 pneumonia.
Author(s) nameTürk MŞ, Akarsu I et al.
Journal Turk J Med Sci
Impact factor
0.62
Citation count: 1
Date of Entry 2021 Nov 1

In a newborn with COVID-19, COVID19 associated coagulopathy (CAG) may have led to the development of pulmonary artery thrombosis.There was an increase in the levels of anti-inflammatory cytokines-Interleukins (IL)-10 and IL-8.
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 		33956761
(Pediatr Infect Dis J)
PMID
33956761
Date of Publishing: 2021 Jun 1
Title Pulmonary Artery Thrombosis in a Newborn With Severe Coronavirus Disease 2019
Author(s) nameSchulze-Schiappacasse C, Alarcón-Andrade G et al.
Journal Pediatr Infect Dis J
Impact factor
2.17
Citation count: 1
Date of Entry 2021 Sep 5

The study identifies adrenal hemorrhage as one of the possible complications of COVID-19. The physiological stress of severe COVID-19 combined with anti-coagulant therapy most likely led to adrenal hemorrhage. The patient suffered a cardiac arrest on Day 5. An echocardiogramgram (ECG) showed the dilated right ventricle with interventricular septal bulging and severe tricuspid regurgitation.
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 		33815638
(Radiol Case Rep)
PMID
33815638
Date of Publishing: 2021 Jun
Title Bilateral adrenal hemorrhage in a man with severe COVID-19 pneumonia
Author(s) name Elkhouly MMN, Elazzab AA, Moghul SS.
Journal Radiol Case Rep
Impact factor
0.6
Citation count: 5
Date of Entry 2021 Sep 5

Gastrointestinal samples from COVID-19 patients who had undergone gastrointestinal procedures were analysed by histopathology and in situ hybridisation (ISH). The findings were either normal with the presence of virus detected by ISH and next-generation sequencing (NGS) or bowel ischemia without the presence of viral particles in the tissue.
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 		33961007
(Arch Pathol Lab Med)
PMID
33961007
Date of Publishing: 2021 May 7
Title Pathophysiology,human,clinical features.
Author(s) nameWesterhoff M, Jones D et al.
Journal Arch Pathol Lab Med
Impact factor
4.27
Citation count: 4
Date of Entry 2021 Sep 5

Lungs of Covid-19 patients and patients who died of influenza were compared with uninfected lungs. Alveolar damage with perivascular T cell infiltration was the predominant feature in the infected lungs. Lungs from COVID-19 infected lungs also showed severe endothelial injury with the presence of intracellular virus. A multiplexed analysis showed that a total of 69 angiogenesis-related genes were differentilly regulated only in covid-19 group, when compared to 26 in the influenza group. 45 genes had shared changes in expression.
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 		32437596
(N Engl J Med)
PMID
32437596
Date of Publishing: 2020 Jul 9
Title Pulmonary Vascular Endothelialitis,Thrombosis and Angiogenesis in Covid-19.
Author(s) nameAckermann M, Verleden SE et al.
Journal N Engl J Med
Impact factor
37.91
Citation count: 2219
Date of Entry 2021 Sep 5

Blood coagulation data in patients with COVID-19 infection was assessed. Compared to the healthy controls, the anti-thrombin values in COVID-19 patients were lower. The levels of D-dimer, fibrin/fibrinogen degradation products (FDP) and fibrinogen (FIB) was higher in the COVID-19 patients when compared to healthy controls.
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 		32172226
(Clin Chem Lab Med)
PMID
32172226
Date of Publishing: 2020 Jun 25
Title Prominent changes in blood coagulation of patients with SARS-CoV-2 infection
Author(s) nameHan H, Yang L et al.
Journal Clin Chem Lab Med
Impact factor
3.59
Citation count: 531
Date of Entry 2021 Sep 5

A patient infected with Covid-19 pneumonia, developed severe hypoxia during hospitalisation. Extensive accumulation of air was seen in the centre of the chest (pneumodiastinum) extending into soft tissue around the neck and mediastinal spaces of the heart.
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 		33948800
(J Gen Intern Med)
PMID
33948800
Date of Publishing: 2021 May 4
Title Spontaneous Pneomodiastinum in a patient with Covid-19 pneumonia.
Author(s) name Alavian N, Stephens JR, DeWalt DA.
Journal J Gen Intern Med
Impact factor
2.39
Citation count: 1
Date of Entry 2021 Sep 29

Acute kidney injury and/or heavy proteinuria was observed in COVID-19 patients with mild symptoms. The majority of these patients developed irreparable renal damage and required dialysis. Weeks after getting COVID-19, two of the three transplant recipients developed active antibody-mediated rejection. Since majority of the patients had mild symptoms, the kidney disease was managed with diuretics and blood pressure control. 7/12 patients showed improvement and 8 patients required dialysis.
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 		33045255
(Am J Kidney Dis)
PMID
33045255
Date of Publishing: 2021 Jan
Title Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting With Acute Kidney Injury or Proteinuria
Author(s) nameAkilesh S, Nast CC et al.
Journal Am J Kidney Dis
Impact factor
5.59
Citation count: 58
Date of Entry 2021 Sep 29

Pregnant women with SARS-CoV-2 infection who were asymptomatic reported miscarriage and pre-term labour, respectively. In both cases, the virus was found in the placenta using qRT-PCR. However, staining of the placental tissue did not show the presence of the virus.
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 		33257773
(J Perinatol)
PMID
33257773
Date of Publishing: 2020 Nov 30
Title Detection of SARS-CoV-2 in placental but not fetal tissues in the second trimester
Author(s) nameValk JE, Chong AM et al.
Journal J Perinatol
Impact factor
3.6
Citation count: 6
Date of Entry 2021 Sep 29