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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DLK1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 8788 Official gene symbol DLK1 Full name delta-like 1 homolog (Drosophila) Aliases ,DLK,FA1,PREF1,Pref-1,ZOG,pG2, Gene summary This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq] Location Chromosome: 14   Locus: 14q32 Gene position 101193202 - 101201467  Map Viewer Gene orientation plus Gene size 8266 bp Gene sequence >DLK1:82193202..82201467:Length=8266 GAAAAGGGCGGCGCGCGCGGCGGCGGCGGCAGCTCCCCGGCAGCGGCGGTGGAGAGCGCA GCGCGCAGCCCGGTGCAGCCCTGGCTTTCCCCTCGCTGCGCGCCCGCGCCCCCTTTCGCG TCCGCAACCAGAAGCCCAGTGCGGCGCCAGGAGCCGGACCCGCGCCCGCACCGCTCCCGG GACCGCGACCCCGGCCGCCCAGAGATGACCGCGACCGAAGCCCTCCTGCGCGTCCTCTTG CTCCTGCTGGCTTTCGGCCACAGCACCTATGGTGAGTTCCCCGGCGGCCCGGCTCGCGCC CCCTCTGGGGAAGCCTGCGACTCCCCGCCGGCCGCCCGGTGCCCCGCACGCCCCGTCTCG TGAGCCCCAACTCCGCCCGTCCCGCCTAGCCCTAAGCCCCGCGCTGTGCCTGTCTCGCCC TACCCACCACGCTCGCATGCCAAGGCCCGTCCCAGGGGTCCCAGGGCGCAGGGGATGTGT GAGACCCCCAGCCCCTTCCCGCCCTGCAGAAGTGGCGCCAGAGGGGTGTCGGTGCGCTGA GCAAGGAGGTATGGAAAAATGGGGTGCTGTTGTGGAGTCTTCTATGAAAATACTCTGGGG TGCAACTTTGGGGTGTCCCTGTGTGAGCGTTCTGGAACAGGTCTCGGGGCGGGAGTGGGG GACGACTTTGCCGTCTTAGCCCCCAATTCCCAGAGAAGCCCAGCCTGAGCCCTTCCTGCG TGGCGCGTTTCTGTAGGTGAGGGGCTGCGACACTTCTGTCTGCAGCGGCCATCTGTCTCT GACAGCGAGAGAGTTGCCCCCTTCCTGCAGCGCCCCCCCACTCATTGCACCAGTGGTTGT AAGGGGGCTGTCTAGAAAGCTGGGGAGCTGGTTGAGTAAATGCACACAGTAGGTGCCTGT TAAAGTGTCAGAATCTCTAAGCAGTGTTGTTGCAACCTCAGCCCGCTAAGCAAAACCCTG TGTCGTCATCGTTTTTTTAATGCGAAGAGTCTGGGGTAGGGGAAAGAGGGAAGATTTGAC CTGGGTGCCCGGCTTAATAGGGATGAACCTTAAAAAGAATGCAGACGCCTTACTGGGGCG CCCACCAGGTGAACCTGTCTGGGCTTTCCCGGAGTTGAACACCTCAAAATCTGCTCCTCT TTTCAGCTCAGGTTGCAAAAGTGACGGTCAGGCTGCATGCCCAGGGCTCAACATATTTCC CTCCACGGTCCCCGTCCCCGCTGTTAGGAGGACTTGAGGTGTCGTATTTGCTTTTGGGAG TCCGAGGAGAAGGTGTTTCTCCTGCTCCTAAGAACGAGGGAGAGTGTACTGTGGTCATTT CATTGCTGGGAACGTGGCAGAGATGTTTTTCCTGAGTGCACTGAGCCCCATCCATGCTCG GATAGGAAGTGCCTACTGTGTGCCAGGCTGGTAGGACCCAAGAGGGCTGTTGGTGCCCTC GAGGGCAGTGGTGGGCTGTGTGGGCGAAGACAGCCTTTGCCTTGGCCTGGGGCCTGGTGG GGTGAATTGTATAACCTTTCTTGTACCTCAGGGGCTGAATGCTTCCCGGCCTGCAACCCC CAAAATGGATTCTGCGAGGATGACAATGTTTGCAGGTAATAGAGTGGCTCCTCAGAGGCA GCTTGTAGGGGCCACGCAGAAGCCTGGGGAGTCGTGAAGTCAGGCAGAAAAAAATAGGGG GCTTGGCCACTACGCTGCAGCAAACAGCTTCCGGGCCCCTGCAGAAAACTGGTGGGGCGA GCTGGGGAGATGGGGGGGGCGGGGGGGGGGCAGCCACAGCTCCTGTCTGCGTTCTCAGAG GTGGGGGGGCAGGTGGGACCACTGCAGGCCACTGCGGCAAAACGCAGCACTCCCCCGGGA TCTCGGGGCCCCTCCAAGTCGGCCCCCTCAGCTTGGCATGTTTTCTCTTTAAGTTTTCCC ATTCAGGTGGCTGGTGTTTACTTCCCAGGACCACCGGCTGCCACTGTGCAAAGACCCCCA AGGGTCCTTGGTTCCACAGAAAGTAGCCTGAGCTGCCTCTCTACCCCTGCCCTCTTCATA TGTCCCCACCTTTCTCCCCCACCCATTGCAGGTGCCAGCCTGGCTGGCAGGGTCCCCTTT GTGACCAGTGCGTGACCTCTCCCGGCTGCCTTCACGGACTCTGTGGAGAACCCGGGCAGT GCATTTGCACCGACGGCTGGGACGGGGAGCTCTGTGATAGAGGTTGGCACTCGCCTTTGT TCACCTCAGCTCTGCGTCCTTACCTGCCTGCCCTAGCCCCTACCACCTCCTCCCAGTCTC CTGTTGCTGGTGTTCCTCACTTCCTCATTCCTGCACACTCCGTGCCCTGTATTCTAAAGA TCTGTTTATAAATTTCCTGTGGGTACCGAATGCCTCCTCAGAGGTAGGGACTTTATTTTG CTCTTCTCTGCGCCATCAGCACCCAGCACCTAGAGGGAACATGGCGTGGGGGCCAGGGAG CTGCCTGTTGAATAAAGAGTCACAAAATACACATACAGCTGGGCCGGTGGGACCACAGAC CCCAGGCTGCCTGTCCAGGTCATGGAAGCCCAGTGATGGACAGGGCTCTGGGGATCTCAG AGCTAAGACTCCCTAGAAAAGCACACGCAAGACTGTAAAGAGGCTGCAAACAAACAAACG GGGTGGGGGGTGGCCAGCACTGCTCAGTGGTTGAGGGGCAGGTGCTGAGTCAGGGCCAGG AGGACAGGGCTGGGGGGCCTGGACTGAGTGGGTCAGGTGTAGGGGGAGGCTGCAGTTGGG AAAAGCTGAGAAAGGGTTAAAGTGAAGATGGGTGTTATCTGTTGATTTCATTAATTTATG CAATCTTTGCCTCCATTACCCCAAGCAATTGAGAGTTGGCTGTCACTGCATTTTCAGGCT GCGAAATGTTCGTCTAAGCCCATTTTCATTTGGCAAAACCAGCCCTAACGTTTGAGCAAA CTGAAGTCCACAAAAAAACTCCCAGCTGTGTAGCAGCCTGCCCTCAGGGCCCCTGTCCCT CAGTCCCCAACATTAGTAAAGACGGTACAGATAGGGAAACTGAGGATCAGAGAAGCACAA GTGTCTGCTAAGGAATATGAAAGAAGTTGGGCAAAAAGCCAGCTACAACCCTTTCCCCCA GCCCCAGAAAGAGAGTTAATTTTTATCTTCGATTGCATCTAACATCCTTCCTTAAGGAAC ACCTAAGAGCATTTTGTTGTGGCCCCTGCCCTGTACAGCCAGGGCAGCCGTGGTTCTGAA GCTGAGCTCCCTCCCACCCCAAATTGTCTCTGGTCCTTAATTCCAGCCCCTGCAATATGG TGCAAGGTTTACCCGCAGCTGACTCATGCTCTGGCCAGCATCTCTGCTGCCCCTCACAGA AGCAGCGGCAGCAGCTCTGAGTCGTTTGAGGATCTGGGGGATTCCAGCAAAGCCACCATT TGGGATCAGGGTTAGGCTTTTAGCTTGGAGCCCATCTTTTTGGTATCTAAATGCCGTACA CCCTTGCTGAAATTTTCCGGACAAATGCCTCCCTTCTCATGGGCCCTTGGTATGTCCCCT CCCCACCAAGTTGACAAAGGCAGCCAGCTTGGGGATGGCCAGAGAGTCTGGGGTCCCAGA GAAGACATAGCCCTCCCTCTCCCTTTTTGCCCATCTTTGAGGCTGTCGTGGCCACAGCTG CTGTCCCAGCAGAGACCCCCAAGCAGCCTTTTCCTCAGAGCAGCTTAATTCACCCCTGTC TTGGGGTTGGAGGCTCAGGAGGGCTGATCCAGGATTGGCATAGCAGGGAGAGCTGCAGGG ACAAGCTGGGGGTGGTCGCCAGCTTTTTAGCTTAAATTTAAGATTCTGAGTGACAGGAGA GTCGGGTGCAGAGAATAAGGAGCCTGACGCGGAGGCGCCACGTGCTAATGCCTTGCCGGT GCCGTCCCGTAAAGATAAATCCTCTTTATGTGTCCTTGCACCAAGCCGGGCTTCCATGGA ACACCACGGGGTAGTCCATCAACACAACGTTCAGGCTCTTCCTCCTTGATTGATTGCAGT CTCCCCTCCACGAGGGTGTGGGTCTCTCTGAGAGGGGGAAAAAATACGCACATGTGTGGC CTCAGCACGGGGGATTTCCCCTCCCCCCACCCCCTCCAGCCTGCCTTAGCTTGCTGTGTC TCTCACTGGCCCTGGCTTTCTGTTTGGCAGGTACAGCAGCTCAAATTATAGAAAATCAAA GCTGAAGAGTCCCTCAGAGATTGGCCAGGGAAAGACCCTCTTTTTATAAGTAGGGAAACT GAGGCCCAGAATGGGTAGGAGCTGAACTCTGCTGCCACATGGCAGCAGGCCGGATACAGG GCAGGACAGGGGTCCCTTCCTGGCCCCACTGGGGAGCTGGGGTCTCCATCATCAGAGAGC CCCTGACTCAGGCCCTTGTGTTCAGCTCATCCCTGGCTTGCTGAACCTGAATAATGAAGT GTGCGTGATGGAAGGTGTTAAAAGATGGTGGGAATATACCAGTGCTCATGGAAACCTGTG CTGATAGGAGAGCGCTCAATAGTTCTAATTTCCCTGGCTTTAAAAGATGAAGCCTTTTTA CCAGGGACCCCTTGAGTTCAGAGCCTGAGTGCAGAAAGAGAGACCACAGGGACACGTGGT AGTGCTGGGGTTAACAGGTTTCTTGATTCCTGACGGAGGGGGGTCGTTACATCTCCATCC CCCCCACTGCCCCTCTTTGATGGAAAAGTATGAAGAGCTGGTGGTTTTTCTGAGGGTTGG GCTGTATTCATCCCCCGGCTGGCCAGGACCCCTCCCCTAACAGGAGAGGGTGGAGATGCA GTCTTGTCTGGTGGAGACAGGCCTTAGGGAATCTCAGCTAGGCACGCTGTTGCAGGGAGG GGCATGATGTCCACAGTGAACGTCACGGACATGTCGCTGGATATGGGGTGACCTGGTGCC AGGCAAAGGGAACAGCTATCCTGGCCTGAATATCAGTGGCCACGACTTTCTGATCTGTGA CCTTAGGCAAGGAAACCCCTTCAGCTTCCTGAGCCTCAGCTTACTCACTTCATGGGTTTT TTTGAGGGGGCTCCCTAAACCCTCTTACTCCAGACCCCACTCGGTGGCCATAGAGCCATT TTAAAGCCCACTGGGGCCCGCATCACGCTCGTGTATGGAGAGGAAGCTAAGTTCTCGTCT TCCCCGTCACCCCGCAGATGTTCGGGCCTGCTCCTCGGCCCCCTGTGCCAACAACAGGAC CTGCGTGAGCCTGGACGATGGCCTCTATGAATGCTCCTGTGCCCCCGGGTACTCGGGAAA GGACTGCCAGAAAAAGGACGGGCCCTGTGTGATCAACGGGTAAATATCCTTCCTGTGTGT GATCTAATGAATGCTGCTTTTCATGCGGCCACCAAAGACCCTTTCAGCCTAACCCTGCTG GACCTGTCGTCTGACAAAAGATGAAGTAAGCGCTCATCCTGGCAGCCCCGTAGGGGACCG CCCTGGATGGGAGTATTCACGGGGGAATGTGTCATTGCCATAATTTTTTCAAATGATCCT GAAGGCGATTTCATATTCCCCTGATGTTCTCAAGTCCCGATGCGTGTGAGTGACAGTCGA TCGGAATGATGAACTGACACTCGGAGCTGCGTAATTTTCTAAAGGCAACGTAGTAAAAGA TTGGAGCTCCGCGGGGCTGAGGCTGTTTGTGAAACCCACTTGCTGTATCTCAGGGGGTGG TTTTGGGGAACTGGTGGGCTCTGCAATTGGATTTTCTGGGATGTCTGTGGAGGGAGTTGC CAGGCTGAGAGGTGAAGAGATTGGGCTTCTGCCAGCACGAGAGGAGGTGGGCCAGCTGTC GGCTATCCTCAGTGGGGAAGGGGGCTTTGGGACTCCTGGGCAGCGGACATAACAGACAGA GTGGCCACTGTCTTCACTTGGACCTCCCTGAACAATGCTTCCCAGCAGCTCAGCCTCTGC CCACCCATTATCTCTTTGGCGGCCCTGAGCCATCCCTCCCCGCTGGATGGGGCTTAGCCT GAAGCCAAGGGAGATCTTGACAGAGGCAGGGTCCGAATGTAAGAATCCAAACTTGAACCC AGTCCTGGGCCTGTAGTTGGGGGGCAGGGGTGTCCCTTTCCTCTGAAGAAACAGAAGCTA ACATGCAAATAAGCTTATCTTGACCGGACATCGCAGGGTGGCACAGAGACCCCAGTAGTC TGTAAGAGCTGTAAACAGACATTAACGGGGCTTCCAAAGATCAGTCTTCAGACGGGGTCA GAGTGGGGGCTGGTGAAGACTGAACTCCATTTCTGCTTATTAGCAGGAAGGAGAAAAACA GAGCGAGACCTTTAAAATATTTTGCTTTTCTCGCGAATGGACTTAAACCAGTGTGTCAAA ATAGAGCCTAAGGCCCTTGAAATTCCTTCAGAGCCCAGCTCCCATGCAGCCCACACCCTG AAGCAGCAGTGCTGATTTCTTGTGTTTACTGCCCCTTCTTCCCCGGAGTTTTGCCATTTA TCGGATGACAAAGGGCTCGCTCGTTTAAAAGCACTTACATTAAATGCTCCTTGTACTCCA CTTTGAGCAAACAGCTTTGGTTTGCAAGCTGCACTTGGGTGAATGGACCACTATTAAACA GCCTGGTACAGACGCTGGCTTGTGCCACCGTAGACAGACCTCGTATTGCTTTCTCTTTGA GAGTCCCCAAGCGCTTCCTGCACAATAGCCTGTGGATCCACACCGCTAATAATAATAATA ATAATAATGAGGGTTGGCGGCAACAGTGGACATAGGCATGAAGGACGACAGCGGGTCCCG GGATAGAGTGAGGGGCGCCCCTTGCTTGGTTCTTCTGCCCCAGCAGTCCAGGGATGGAGC TAAGGGAAGGGGGCTTGCTCCAGTCCTGGGCTGTCACTGACTTTTCCTCTCCTAGCCTCA GTTTCCCCAGTTGGCTAGTGACTAACCGGTTGGAGACTAACCTCTGGTTGGAGAGGTGCA GTAAGAGGTGGGAGAGGACGTGGGCATCCTGGCATGGGAGGTCGGGTGTGTCCCAGGTTA GCATCGAGATGGGGGTGAGGTGGGCACCCACCCACCCACCCCCAGAGCTACTGGTGAGCT TCTCGCAGACAGGGGTCACGGCCCCGGGCACCTCTCTGTGCCTCCCTGGCTGGCGTTCCC TCCCTCGCTCCCTCATTCACCTGATGTGTTTTAAGCACCTGCCCCTTAGTCAGGCCAGGG ACCTTCTGCCCTGAGCCCCGTGCCCTGCAGCGCTGTTGTAGCCTAGCCCCTGAGGCCGTT TACTATGTCCCTGTTGTGTTGCAGCTCCCCCTGCCAGCACGGAGGCACCTGCGTGGATGA TGAGGGCCGGGCCTCCCATGCCTCCTGCCTGTGCCCCCCTGGCTTCTCAGGCAATTTCTG CGAGATCGTGGCCAACAGCTGCACCCCCAACCCATGCGAGAACGACGGCGTCTGCACTGA CATTGGGGGCGACTTCCGCTGCCGGTGCCCAGCCGGCTTCATCGACAAGACCTGCAGCCG CCCGGTGACCAACTGCGCCAGCAGCCCGTGCCAGAACGGGGGCACCTGCCTGCAGCACAC CCAGGTGAGCTACGAGTGTCTGTGCAAGCCCGAGTTCACAGGTCTCACCTGTGTCAAGAA GCGCGCGCTGAGCCCCCAGCAGGTCACCCGTCTGCCCAGCGGCTATGGGCTGGCCTACCG CCTGACCCCTGGGGTGCACGAGCTGCCGGTGCAGCAGCCGGAGCACCGCATCCTGAAGGT GTCCATGAAAGAGCTCAACAAGAAAACCCCTCTCCTCACCGAGGGCCAGGCCATCTGCTT CACCATCCTGGGCGTGCTCACCAGCCTGGTGGTGCTGGGCACTGTGGGTATCGTCTTCCT CAACAAGTGCGAGACCTGGGTGTCCAACCTGCGCTACAACCACATGCTGCGGAAGAAGAA GAACCTGCTGCTTCAGTACAACAGCGGGGAGGACCTGGCCGTCAACATCATCTTCCCCGA GAAGATCGACATGACCACCTTCAGCAAGGAGGCCGGCGACGAGGAGATCTAAGCAGCGTT CCCACAGCCCCCTCTAGATTCTTGGAGTTCCGCAGAGCTTACTATACGCGGTCTGTCCTA ATCTTTGTGGTGTTCGCTATCTCTTGTGTCAAATCTGGTGAACGCTACGCTTACATATAT TGTCTTTGTGCTGCTGTGTGACAAACGCAATGCAAAAACAATCCTCTTTCTCTCTCTTAA TGCATGATACAGAATAATAATAAGAATTTCATCTTTAAATGAGTAA OMIM ID 176290