| Entrez gene ID | | 55593 |
| Official gene symbol | | OTUD5 |
| Full name | | OTU domain containing 5 |
| Aliases | | ,DKFZp761A052,DUBA,MGC104871, |
| Gene summary | | This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] |
| Location | | Chromosome: X Locus: Xp11.23 |
| Gene position | | 48815648 - 48779301 Map Viewer |
| Gene orientation | | minus |
| Gene size | | 36348 bp |
| Gene sequence |
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| OMIM ID | | 300713 |