| Entrez gene ID | | 51686 |
| Official gene symbol | | OAZ3 |
| Full name | | ornithine decarboxylase antizyme 3 |
| Aliases | | ,AZ3,OAZ-t,TISP15, |
| Gene summary | | Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. In contrast to antizymes 1 and 2, which are widely expressed throughout the body, the expression of this gene product (antizyme 3) is restricted to testis germ cells, and thus it is a possible candidate for heritable forms of human male infertility. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Location | | Chromosome: 1 Locus: 1q21.3 |
| Gene position | | 151735445 - 151743806 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 8362 bp |
| Gene sequence |
| |
| OMIM ID | | 605138 |
|