| Entrez gene ID | | 4939 |
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| Official gene symbol | | OAS2 |
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| Full name | | 2'-5'-oligoadenylate synthetase 2, 69/71kDa |
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| Aliases | | ,MGC78578, |
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| Gene summary | | This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] |
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| Location | | Chromosome: 12 Locus: 12q24.2 |
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| Gene position | | 113416274 - 113449528 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 33255 bp |
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| Gene sequence |
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| OMIM ID | | 603350 |
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