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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FBXO5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID26271
Official gene symbolFBXO5
Full nameF-box protein 5
Aliases,EMI1,FBX5,Fbxo31,
Gene summaryThis gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
LocationChromosome: 6   Locus: 6q25.2
Gene position153304740 - 153291658  Map Viewer
Gene orientationminus
Gene size13083 bp
Gene sequence
OMIM ID606013