| Entrez gene ID | | 26263 |
| Official gene symbol | | FBXO22 |
| Full name | | F-box protein 22 |
| Aliases | | ,FBX22,FISTC1,FLJ13986,MGC31799, |
| Gene summary | | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq] |
| Location | | Chromosome: 15 Locus: 15q24.2 |
| Gene position | | 76196200 - 76226944 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 30745 bp |
| Gene sequence |
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| OMIM ID | | 609096 |
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