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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for F10 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2159
Official gene symbolF10
Full namecoagulation factor X
Aliases,FX,FXA,
Gene summaryThis gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq]
LocationChromosome: 13   Locus: 13q34
Gene position113777113 - 113803843  Map Viewer
Gene orientationplus
Gene size26731 bp
Gene sequence
OMIM ID227600