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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for EIF2S1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1965
Official gene symbolEIF2S1
Full nameeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Aliases,EIF-2,EIF-2A,EIF-2alpha,EIF2,EIF2A,
Gene summaryThe translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM]
LocationChromosome: 14   Locus: 14q23.3
Gene position67827034 - 67853233  Map Viewer
Gene orientationplus
Gene size26200 bp
Gene sequence
OMIM ID603907