| Entrez gene ID | | 1965 |
| Official gene symbol | | EIF2S1 |
| Full name | | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa |
| Aliases | | ,EIF-2,EIF-2A,EIF-2alpha,EIF2,EIF2A, |
| Gene summary | | The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM] |
| Location | | Chromosome: 14 Locus: 14q23.3 |
| Gene position | | 67827034 - 67853233 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 26200 bp |
| Gene sequence |
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| OMIM ID | | 603907 |
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