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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for EGF (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1950
Official gene symbolEGF
Full nameepidermal growth factor
Aliases,HOMG4,URG,
Gene summaryThis gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.
LocationChromosome: 4   Locus: 4q25
Gene position110834040 - 110934118  Map Viewer
Gene orientationplus
Gene size100079 bp
Gene sequence
OMIM ID131530