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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DIO3 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1735 Official gene symbol DIO3 Full name deiodinase, iodothyronine, type III Aliases ,5DIII,D3,DIOIII,TXDI3, Gene summary The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq] Location Chromosome: 14   Locus: 14q32 Gene position 102027688 - 102029789  Map Viewer Gene orientation plus Gene size 2102 bp Gene sequence >DIO3:83027688..83029789:Length=2102 AGCCCAAGATTTCTAGGGCATTGGCCGCGCTGCTGGGTGATCCCTCCGGGCTCAAGTTGC AAGGGGGCGGGCCGGGCCGGAGGTGGAGTCTCCCGCCAATTGAAGCCTCCGCTATAAATT GAACTCCCTGCACTGCTGAAGCCCAGATGCCTCGCCAGGCCACGTCGCGGTTGGTGGTCG GAGAGGGCGAGGGGTCCCAGGGGGCTTCGGGGCCTGCAGCCACCATGCTCCGCTCCCTGC TGCTTCACTCCTTGAGGCTCTGCGCCCAGACCGCCTCGTGCCTCGTGCTCTTCCCGCGCT TCCTCGGCACGGCCTTCATGCTCTGGCTTCTCGATTTCTTGTGTATCCGCAAGCATTTCC TGGGCCGCCGCCGCCGGGGGCAGCCCGAGCCCGAAGTGGAGCTCAACAGTGAAGGCGAGG AGGTGCCTCCCGATGACCCGCCCATCTGCGTGTCCGACGACAACCGCCTGTGCACCCTGG CGTCGCTCAAGGCGGTGTGGCATGGCCAGAAGTTGGATTTCTTCAAGCAGGCGCACGAGG GCGGTCCGGCGCCCAACTCCGAGGTGGTTCTGCCCGACGGCTTCCAGAGCCAGCACATCC TCGACTACGCGCAAGGGAACCGCCCGCTGGTTCTCAATTTCGGCAGCTGCACCTGACCAC CGTTCATGGCGCGCATGAGCGCCTTCCAGCGCCTGGTCACTAAGTACCAGCGCGACGTCG ACTTCCTCATCATCTACATCGAGGAAGCGCACCCCTCCGACGGCTGGGTCACCACGGACT CTCCCTACATCATCCCACAGCACCGGAGCCTGGAGGACCGGGTCAGCGCAGCGAGGGTAC TGCAGCAAGGTGCACCCGGCTGCGCTCTGGTCCTCGACACCATGGCCAACTCCAGCAGCT CGGCCTATGGCGCCTACTTCGAGCGTCTCTATGTCATCCAGAGTGGCACTATTATGTACC AGGGCGGCCGTGGCCCCGACGGCTACCAGGTCTCTGAGCTGCGCACTTGGTTGGAACGCT ATGATGAGCAACTGCACGGCGCTCGGCCCCGGAGGGTGTAAACATCCAACGGACAATTGA CTGAACTTGGTGGGCTGGGCCTTCGAGCCTTCGAAGCCCACGTGCAAGCGCCTCAAACCA AGTCACGCTTGGCGAGGCCCCAGTGACACTGATGTGCTGAGCCACCATTTCAGACTGAGT CTGCACCCTCAGCCACATGAACAATCTCCCCTACCTCCCTGGGACTCTGCTTCTGTAACT GTCTCATTCACACCTGCCTGGCTCACTGGAAATCCTCTTTTGAGCGCGGGATATGGCTTG CCCTTGTCCGTGTGCCCCCAGGACTTTGCCTCTACAGCATTTTCTTACACCCCCTCCCCA GCGTGCCCTCAGCCAAGTGCTTTGGCCCGGTGCTTCCCGCAGCTGCACAGAGACCTTGGC CACGCCCGCGCGCCCTGAGCGCAGCTGGGTTCCAGGAGACTCTCAGCTCAGCTGAGCTAG TTGCCTGGCACCCACCTGTCGCGCGCGGAGAGGGGGTTCCCTGTTGCTTTTGTGTCTGTT TCCTGTCCCTGGTAGGGGAAGTGATGTCGTGGATGGGGAGGGGTGGGCAGGGTAGTTTCC CCCGCTTGTTTTGGGTGCACAGGAGCCCCACTGCTGATGACGAACTATCTCTAACTGGTC TTGACCACGAGCTAGTTCTGAATTGCAGGGGCCTCAAAGCAGCACCTAAACCTTGAGGGG GAGGGTGCTCTGGGTTTCCGTGAGGTAACCACCTTAAATGGGAGGGAAGTTGGGGTGTCT GCTTTGGGACCAGAGGAAGATAGCTTGAGAGGCATTGGCGAGGTTCGCAGCGCCCCAGGG AGAGAGAAAAAGCTGAGACTCCTGGGGAATGACGTTGGGGTGATGGAGTCCGGGGAAAGA GAGGTGGGGGGAGAGCCTGAGGTCCCCAAGTGAGGGGAGTCCTAGGCAGAGCTGCTGATT GTGGGGCTGGGAGGTGGAGGGCCCCTGATTCGAAGGCCATTTGGTGAGTGTTTTGCTGGA AATATTTCCTGTATATAAACTTCTTTCAATCTACAATAATAAAGGCTTGAGGTAAACTGC TT OMIM ID 601038