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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DCTN1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1639
Official gene symbolDCTN1
Full namedynactin 1 (p150, glued homolog, Drosophila)
Aliases,DAP-150,DP-150,HMN7B,P135,
Gene summaryThis gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq]
LocationChromosome: 2   Locus: 2p13
Gene position74619214 - 74588281  Map Viewer
Gene orientationminus
Gene size30934 bp
Gene sequence
OMIM ID601143