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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FBXO32 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID114907
Official gene symbolFBXO32
Full nameF-box protein 32
Aliases,FLJ32424,Fbx32,MAFbx,MGC33610,
Gene summaryThis gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing of this gene results in two transcript variants encoding two isoforms of different sizes. [provided by RefSeq]
LocationChromosome: 8   Locus: 8q24.13
Gene position124553446 - 124515358  Map Viewer
Gene orientationminus
Gene size38089 bp
Gene sequence
OMIM ID606604