| Entrez gene ID | | 114907 |
| Official gene symbol | | FBXO32 |
| Full name | | F-box protein 32 |
| Aliases | | ,FLJ32424,Fbx32,MAFbx,MGC33610, |
| Gene summary | | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing of this gene results in two transcript variants encoding two isoforms of different sizes. [provided by RefSeq] |
| Location | | Chromosome: 8 Locus: 8q24.13 |
| Gene position | | 124553446 - 124515358 Map Viewer |
| Gene orientation | | minus |
| Gene size | | 38089 bp |
| Gene sequence |
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| OMIM ID | | 606604 |
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